Aspect Medical Systems, Inc.

Nellcor Puritan Bennett Incorporated

Lifeline Systems, Inc.

Philip H Devlin

Nassib G Chamoun

John R Shambroom

Scott D Greenwald

Rafael M Cordero

Charles Fendrock

Terrie L McDaniel

Charles P Smith

Jeffrey C Sigl

Todd A Marcus

Mark E Bruckner

Edwin B Merrick

L Dennis Shapiro

Richard M Reich

Theodore Bially

Robert M Armington

Tim Kofol

Joao Melo

The present invention is a system and method of deriving and computing features and indices that predict the likelihood of psychological and neurological adverse events such as suicidal thoughts and/or actions. The method of the present invention further predicts the likelihood of suicidal thoughts and/or actions prior to and or during treatment for psychological disease. To obtain such features and indices, power spectrum and time domain values are derived from biopotential signals acquired from the subject being tested. The system and method identify people who are likely to experience changing, especially worsening, symptoms of psychological and neurological adverse events such as suicidal thoughts or actions and who therefore may be at risk (e.g. suicide).

System and method for prediction of adverse events during treatment of psychological and neurological disorders

The invention provides a method of estimating cerebral sources of electrical activity from a small subset of EEG channels utilizing existing methods to provide a 3-dimensional, discrete, distributed, linear solution to the inverse problem using inputs consisting of a small number of EEG channels (e.g., 4 channels) augmented with synthetic EEG data for the other channels. The resultant image of cerebral electrical activity in the region of the EEG channels from which data is recorded is of comparable spatial resolution in the corresponding region to images of cerebral electrical activity obtained using a complete set of EEG channels (e.g., using 24 channels).

System and method for EEG imaging of cerebral activity using small electrode sets

Disclosed is a system and method of assessing the efficacy of and predicting response to treatment of neurological or psychological disorders. The preferred embodiment uses at least two surface electrodes to acquire EEG signals from the surface of a patient's body, a processor for computing from the EEG signals various features and indices that are representative of the patient's neurological or psychological state. Pretreatment indices represent a patient's neurological or psychological state and therefore may be used to predict the response to treatment. Changes in these parameters may be used to assess the efficacy of treatment and to modify the treatment to optimize the resultant patient state.

System and method of prediction of response to neurological treatment using the electroencephalogram

Disclosed is a system and method of assessing the efficacy of treatment of neurological or psychological disorders. The preferred embodiment uses at least two surface electrodes to acquire EEG signals from the surface of a patient's body, a processor for computing from the EEG signals various features and indices that are representative of the patient's neurological or psychological state. Changes in these parameters may be used to assess the efficacy of treatment and to modify the treatment to optimize the resultant patient state.

System and method of assessment of the efficacy of treatment of neurological disorders using the electroencephalogram

The present invention is a system and method that produces features and indices that indicate the presence or absence of a disease or condition, or of the progression of a disease or condition. The system and method of the present invention also produce features and indices that predict responsiveness to medication from a premedication baseline. The system and method of the present invention further incorporates a testing methodology to improve the performance characteristics of the features or indices. To obtain such features and indices, time domain, power spectrum, bispectrum and higher order spectrum values are derived from biopotential signals taken from the subject being tested.

System and method of assessment of neurological conditions using EEG

An array of electrodes is constructed to allow the user to easily adjust to the correct size of the patient's head. The array is self-adhesive, pre-gelled and disposable. The array fits easily over the temple and forehead areas where EEG signals can be acquired by specially designed monitors for purposes of monitoring a number of bodily phenomena, including but not limited to, depth of anesthesia, and/or ischemia, and burst suppression. The array is connected to the monitor via a tab connector that is integral to the disposable device. The tab connector is insertible into a reusable connector that is part of a monitoring system.

Electrode array system for measuring electrophysiological signals

An electrophysiological electrode includes multiple layers of materials to isolate liquid electrolytic gels from the conductive inks on the flexible circuit of the electrode substrate. Such an electrode has a much longer shelf life under normal storage conditions than other electrodes of such construction with high salt content liquid electrolytic gel, and is able to maintain acceptable impedance upon its eventual use.

Electrode for measuring electrophysiological signals using liquid electrolytic gel with a high salt concentration

Disclosed is a system and method for providing information to the user of a medical monitoring or diagnostic device to aid in the clinical decision making process. The preferred embodiment uses two estimators or predictors of the same physiological quantity, with each of the estimators being designed to detect specific states or artifacts in the estimated parameter and thus operating at a different point on its respective ROC curve; one chosen to provide high sensitivity, the other chosen to provide high specificity. The divergence between the estimators is indicated by the use of a shaded region between their respective time trends. The use of 2 estimators of the same parameters with different performance characteristics allows the system and method of the present invention to derive additional information about the underlying physiologic process over and above that which would be available from a single estimator. The system and method of the present invention can derive information from not only the instantaneous values of the estimators and the difference between them, but also from the time trend of the difference.

System and method for facilitating clinical decision making

A sensor system which includes a biopotential signal monitor, a smart sensor and the accompanying hardware and software interface which authenticates the source and validity of the smart sensor and also verifies that the smart sensor meets various criteria for use.

Smart electrophysiological sensor system with automatic authentication and validation and an interface for a smart electrophysiological sensor system

Disclosed is a physiological electrical signal connector system which one connector connected to an electrode set and another connector connected to a digital signal convertor which leads to a patient monitor. Each type of electrode set has a specific code identified with it and when connected to the digital signal convertor, the connector code is recognized by the digital signal convertor. The connector code is then relayed to the monitor which will self-configure based on the identified code.

Electrode connector system

Disclosed is an electrode array (i.e., 'sensor') and a method for separating near and far-field signals. In one embodiment a horizontal array is used, and in an alternate embodiment a vertical array is used. The electrode array consists of two well-separated pairs of closely spaced electrodes (and a separate ground element). In a typical application of collecting a channel of EEG, 'sensing' electrodes are placed in standard locations (e.g., R and Ctr) with a ground electrode placed elsewhere on the head. The voltage measured between the well-separated sensing electrodes is the far-field dominant (i.e., EEG-dominant) channel. Additional electrodes are placed near each of the two sensing electrodes. (The additional electrodes are immediately lateral to the existing electrodes in the horizontal array, and are immediately above the existing electrodes in the vertical array.) The voltages measured between the pairs of closely spaced electrodes are near-field dominant (i.e., EMG/EOG-dominant) channels. The EEG, EMG and EOG signals can be enhanced by uncoupling them by combining information from all channels. The sensor is connected to a monitor via a patient interface cable (PIC). The sensor contains additional circuitry at the connection site that is used by the monitor to identify the presence and type of sensor, and to configure the monitor to invoke the appropriate software that will apply the method of the current invention to collect and uncouple the EEG, EMG and EOG.

Method for enhancing and separating biopotential signals

A personal emergency response system (PERS) is disclosed which includes a method and apparatus for monitoring alarm signals to provide improved emergency response capabilities and enhanced system operability. The system includes a local response center for relaying alarm signals received from subscribers to mobile on-site field personnel via individual paging units. The system is also capable of retransmitting an alarm signal in the event that a response to the original alarm signal has not been registered within a predetermined period of time. The system is also provided with redundant communications paths to minimize the possibility of a missed alarm message from a subscriber, and self-test capabilities for detecting system faults and transmitting fault messages to the individual paging units of the system.

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Brookline, MA, United States of America

Philip H Devlin