Massachusetts Institute of Technology

Philip Fremont-Smith

James Douglas Harper

Eric D Schwoebel

Martha Susan Petrovick

Darrell Orlyn Ricke

Brian S Helfer

Anna Shcherbina

James G Watkins

Edward C Wack

Adam M Michaleas

Joseph Isaacson

The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.

Systems and methods for genetic identification and analysis

Growing community of inventors

Medford, MA, United States of America

Philip Fremont-Smith