Mallinckrodt, Inc.

Philip E Wiegert

George Brooke Hoey

James W Woods

George P Murphy

Certain 3,5-disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids are useful as x-ray contrast agents. Representative of this class of compounds is the compound 3-gluconamido-2,4,6-triiodo-N-methyl-5-(N-methyl-acetamido)-benzamide and the compound 3-gluconamido-5-[N-(2-hydroxyethyl)acetamido]-2,4,6-triiodo-N-methylbenzam ide.

3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids

5-Gluconamido-2,4,6-triiodo-N-methylisophthalamic acid, 3-acetamido-2,4,6-triiodo-5-trishydroxymethylacetamido-benzoic acid, related compounds and salts and esters thereof are useful as x-ray contrast agents. The corresponding acyl halides are useful as intermediates.

2,4,6-Triiodobenzoic acid derivatives and their use as x-ray contrast

Certain N-[poly(hydroxyalkyl)alkyl],2,4,6-triiodoisophthalamic acids are useful as x-ray contrast agents. A representative compound has the structure ##STR1##

Substituted isophthalamic acids

5-Gluconamido-2,4,6-triiodo-N-methylisophthalamic acid, 3-acetamido-2,4,6-triiodo-5-trishydroxymethylacetamidobenzoic acid, related compounds and salts and esters thereof are useful as x-ray contrast agents. The corresponding acyl halides are useful as intermediates.

X-ray contrast agents

Certain N-[poly(hydroxyalkyl)alkyl], 2,4,6-triiodoisophthalamic acids are useful as x-ray contrast agents. A representative compound has the structure ##STR1##

Substituted 2,4,6-triiodoisophthalamic acids

2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts and esters thereof are useful as x-ray contrast agents. The corresponding acyl halides are useful as intermediates.

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St. Louis, MO, United States of America

Philip E Wiegert