Mcgill University

Philip E Branton

Gordon C Shore

Mai Nguyen

Florence W H Ng

Richard C Marcelius

Josee N Lavoie

Jose G Teodoro

The invention features E4orf4-encoding nucleic acids, pharmaceutical compositions and expression vectors containing the same, and methods for their use. E4orf4-encoding nucleic acids include (i) nucleic acids capable of hybridizing at high stringency to the complement of the nucleic acid encoding Ad2E4orf4, and (ii) nucleic acids having 50% or greater nucleotide sequence identity to the nucleotide sequence of Ad2E4orf4, so long as the nucleic acids encode a polypeptide capable of inducing apoptosis.

Adenovirus E4 proteins for inducing cell death

The invention provides a novel apoptosis protein: p28 Bap31. Also provided are p28 Bap31 polypeptide fragments, p28 Bap31 antisense nucleic acid molecules, anti-p28 Bap31 antibodies, and methods for modulating apoptosis and for detecting compounds which modulate apoptosis.

Methods and reagents for modulating apoptosis

The invention features p28 Bap31 polypeptides and nucleic acids. The invention also features methods for modulating apoptosis using these polypeptides and nucleic acids, and methods for identifying apoptosis-modulating compounds.

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CA

Philip E Branton