Amgen Inc.

Philip Dean Ramsden

Vatee Pattaropong

Jonathan B Houze

Nobuko Nishimura

Zhihua Ma

Paul John Dransfield

Wen-Chen Yeh

Su-Jen Lai

Gayathri Swaminath

Yinhong Chen

Aarif Yusuf Khakoo

James S Harvey

David John Kopecky

Julie Anne Heath

Mikkel V Debenedetto

Ankit Sharma

Sujen Lai

Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: Figure I and Figure II where the definitions of the variables are provided herein.

Substituted pyrimidinones as agonists of the APJ receptor

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein. 

Alkyl substituted triazole compounds as agonists of the APJ Receptor

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein. 

Cycloalkyl substituted triazole compounds as agonists of the APJ receptor

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Philip Dean Ramsden