Si Group, Inc.

Philip David Atwood

Cornelius Haase

Kelly S Chichak

Ricky Biittig

Allyson Staats

Jim Webb

Jeff Hiscock

This invention relates to a process for preparing a calixarene compound by reacting a phenolic compound and an aldehyde in the presence of at least one nitrogen-containing base as a catalyst to form the calixarene compound. The invention also relates to processes for high-yield, high solid-content production of a calixarene compound, with high selectivity toward a high-purity calix[8]arene compound, without carrying out a recrystallization step.

Processes for preparing calixarenes

This invention relates to a one-pot synthesis of a high-purity calix[4]arene compound by reacting a phenolic compound and an aldehyde in the presence of at least one nitrogen-containing base as a catalyst to form the calix[8]arene compound, and cleaving the calix[8]arene compound into a high-purity calix[4]arene compound, directly, without carrying out a purification step before the cleaving step. The invention also relates to an improved conversion of a calix[8]arene compound to a calix[4]arene compound, by cleaving a calix[8]arene compound in a glycol ether solvent having a boiling point of at least about 200&#xb0; C., to result in a high-purity calix[4]arene compound, without using an antisolvent.

Processes for preparing calix[4]arenes from calix[8]arenes

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Schenectady, NY, United States of America

Philip David Atwood