British Technology Group Limited

Philip D Minor

Jeffrey William Almond

Michael A Skinner

Colin R Young

Andrew Joseph MacAdam

David Michael Stone

An attenuated poliovirus in which the 5' non-coding region of the genome is:

Attenuated polyiviruses vaccine containing them and vaccination methods

An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has a reversed base pairing in the part, or in a part corresponding to the part, of the 5' non-coding region of the genome of poliovirus type 3 Leon strain shown below: ##STR1## A suitable attenuated poliovirus has the bases G and C at positions 469 and 534 respectively for a type 1 or type 2 poliovirus or at positions 472 and 537 respectively for a type 3 poliovirus.

Attenuated viruses

An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has an attenuating mutation at least at a position which is, or corresponds with, position 471 or 484 of the genome of poliovirus type 3 Leon strain.

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Potters Bar, United Kingdom

Philip D Minor