General Electric Company

Whatman International Limited

Ge Medical Systems Global Technology Company, LLC

Global Life Sciences Solutions USA LLC

Global Life Sciences Solutions Operations UK Ltd

Qiagen Healthcare Biotechnologies Systems Gmbh

Philip Alexander Shoemaker

Weston Blaine Griffin

Erin Jean Finehout

Jaydeep Roy

Xuefeng Wang

Kashan Ali Shaikh

Stefan Rakuff

Greg Darryl Goddard

Darren Lee Hallman

Erik Leeming Kvam

James Mitchell White

Xiaohui Chen

Eric Douglas Williams

Aaron Joseph Dulgar-Tulloch

Zaeem Ashraf Khan

Mark Ernest Vermilyea

Jeffrey Wayne Eberhard

Prabhjot Singh

Zhipeng Zhang

Thomas Joseph Fyvie

Arvind Rangarajan

Andrew Michael Leach

Henri Souchay

Bowden Kirkpatrick

Paul Michael Ratzmann

Nichole Lea Wood

Teresa Grocela Rocha

William Patrick Waters

Owen Scott Quirion

Ajay Kapur

Abdulrahman Abdallah Al-Khalidy

Ryan Austin Hutchinson

Diego Quinones

Terrence Paul Vernes

Robert Jeffrey Pieciuk

Greg D Goddard

Erin Finehout

Zaeem A Khan

Eric L Kvam

Aaron Dulgar-Tulloch

Kashan A Shaikh

The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.

Systems, methods and control laws for cell harvesting

Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.

Methods and systems for processing samples on porous substrates

A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer, introducing the adipose tissue into the vessel, introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.

Automated methods for isolating regenerative cells from adipose tissue

A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.

Automated systems and methods for isolating regenerative cells from adipose tissue

An apparatus and method are provided for servicing a dynamoelectric machine component. The apparatus includes a tool delivery mechanism adapted for delivering a tool to a desired location in the dynamoelectric machine, and a tool support fixture adapted to be secured onto the body of the dynamoelectric machine, where the tool support fixture can be used for supporting and adjusting the tool delivery mechanism. A sleeve mechanism is attached to the tool support fixture, and the sleeve mechanism is disposed around a portion of the tool delivery mechanism. The apparatus is adapted to service the component of the dynamoelectric machine in-situ.

Apparatus and method for servicing dynamoelectric machine components in-situ

Automated methods and systems for punching out pieces of a porous substrate for biological samples comprising: loading the porous substrate onto a support comprising a die and an opening; moving a receptacle support in at least a z-direction to position a receptacle relative to the support so that an opening in the receptacle is aligned and substantially flush with the opening in the support; actuating a punching head so that the punching head passes through the die, thereby punching a piece out of the porous substrate; and actuating an ejector pin to eject the punched piece from the porous substrate support and into the receptacle aligned with the opening in the support.

Methods and systems to prevent punch loss during automated sample processing

Disclosed herein is a disposable fluid path for processing complex materials. The disposable fluid path comprises a gravity assisted disposable system for separating a biological sample into two or more distinct submaterials through sedimentation. The fluid path is comprised of a sample delivery conduit and bag-set wherein the bag set comprising a tubing assembly, a separation assembly, and a filter assembly. Methods of using the system are also disclosed.

Disposable fluid path systems and methods for processing complex biological materials

The invention provides a method of manufacturing a housingless hollow fiber filtration apparatus using batch, continuous, and semi-continuous processes. Also provided is manufacturing methods to increase rigidity of the apparatus.

Methods for making a housingless hollow fiber filtration apparatus

A method is described for making a composite laminate formed by curing a stacked structure comprising at least two layers of strips of fibrous material impregnated with resin, wherein the strips in adjacent layers have different directional orientations. An apparatus is provided for simultaneously separating a band of fibrous material impregnated with resin into strips and depositing the strips between adjacent pin rows of a pinmat to form the stacked structure.

Method of manufacture of composite laminates, an assembly therefor, and related articles

Disclosed herein is a compression paddle comprising a paddle base; and a paddle wallcomprising a first side-wall; and a second side-wall; wherein the first side-walland/or the second side-wallare disposed upon the paddle baseand inclined with respect to the paddle baseat an angle that is effective to permit an x-ray beam uninterrupted access to an object of interest located on an opposing side of the paddle basefrom an x-ray source when an angle between a central axis of the x-ray beam and a vertical taken at an inner surface of the first side-walland/or the inner surface of the second side-wallis about 15 degrees to about 75 degrees.

Compression paddle for mammography systems

Method and apparatus for recovering and purifying a solvent used in an article cleaning appliance are provided. The method allows passing solvent-based cleaning fluid from a wash basket through a coarse filter configured to remove relatively large particulates from the cleaning fluid. The method further allows passing cleaning fluid from the coarse filter through a particulate filter configured to remove relatively fine particulates from the cleaning fluid. An aqueous phase that may be present in the cleaning fluid is separated by decanting and coalescing through a separator/filter assembly. The cleaning fluid may then be passed through a regeneration cartridge for removing any water that may remain in the cleaning fluid, and for adsorbing organic contaminants that may be present in the cleaning fluid. Recovered solvent may be stored in a tank for subsequent use in a cleaning process performed by the appliance.

System and method for solvent recovery and purification in a low water or waterless wash

An x-ray system is provided that produces noise at or below ambient levels. The system includes a positioning arm, an x-ray tube, an x-ray detector, and an acoustic dampening interface mounting between the x-ray tube and a first end of the positioning arm. The acoustic dampening interface may be a rubber isolator that absorbs the vibrations produced by the x-ray tube. The rubber isolator may include a rubber isolation tube positioned within a hole formed in a mounting plate of the x-ray tube. Alternatively, the rubber isolator may include a rubber washer and a rubber isolation layer, or isolation ring.

X-ray positioning arm noise reduction system

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Scotia, NY, United States of America

Philip Alexander Shoemaker