3m Innovative Properties Company

Minnesota Mining and Manufacturing Company

Kindeva Drug Delivery, L.p.

3m Company

Philip A Jinks

Moses Mekala David

Rudolf J Dams

Peter D Hodson

Paul E Hansen

David J Greenleaf

Christopher G Blatchford

Martin J Oliver

Suresh Iyer

Frans A Audenaert

Robert K Schultz

Tarlochan S Purewal

David W Schultz

Gary H Ward

Charles G Thiel

Graham R Purkins

Danna L Ross

Robert A Moris

Nayna Govind

Trevor J Wilde

Jean A Kelly

Daniel R Hanson

Peter H Howarth

Sukhbinder K Jaiswal

Simon G Paling

Susannah C Boswell

Alexander D Slowey

Vicki M Lietzau

Methods of making components for a medicinal delivery device are described, in which a base composition comprising a polysulphone is applied to the surface of a component to create a base layer, a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group is applied to the base layer to create primed surface, and a coating composition comprising an at least partially fluorinated compound is applied to the primed surface. Corresponding coated components and a medicinal delivery device are disclosed.

Method for making medicinal delivery device having multi-layer coating

A pressurized metered dose dispenser () for dispensing an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the dispenser comprising an aerosol container () equipped with a metered dose valve (), where a formulation chamber is defined in part by the internal walls of the container, and wherein the dispenser further comprises a porous, fluid permeable, particulate semi-permeable body () located within the formulation chamber adjacent to the metered dose valve.

Metered dose dispensers with porous body

The present invention addresses the problem of turbophoresis and provides a relatively simple and low cost solution for a metered dose inhaler, in particular, a pressure-actuated metered dose inhaler. A metering valve () comprises a valve body (), a valve stem () mounted within the valve body () and a spring element () for biasing the valve stem () in an 'at rest' position. A pre-metering region () is formed in the valve stem () which is provided with a miniature valve seal () at its inlet (). The miniature valve seal () effectively isolates the pre-metering region () from surrounding bulk formulation () within a canister () in which the metering valve () is mounted when the valve stem () is in the 'at rest' position.

Metered dose inhalers

The present invention relates to methods of making medicinal aerosol canisters (), in particular metered dose canisters (), comprising aerosol formulation comprising medicament particles suspended in liquid propellant, for example for delivery by pulmonary or nasal inhalation as well as medicinal dispensers () including such canisters (), such as metered dose medicinal dispenser in particular pressurized metered dose inhalers, wherein the liquid propellant in some embodiments contains HFA 134a and/or HFA 227, and the propellant component is subjected to one or more ultrasonic probes.

Manufacture of medicinal aerosol canisters

A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, the at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.

Metered dose valves and dispensers

A medical inhalation device or a component thereof having a diamond-like glass coating comprising hydrogen and on a hydrogen free basis about 20 to about 40 atomic percent of silicon, greater than 39 atomic percent of carbon, and less than 33 down to and including zero atomic percent of oxygen.

Medicinal inhalation device

Medicinal inhalation devices and components having a non-metal coating and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating are provided. In some embodiments, the partially fluorinated compound comprises a polyfluoropolyether silane of Formula Ia:R[Q-[C(R)&#x2014;Si(Y)(R)]]&#x2003;&#x2003;Ia

Medicinal inhalation devices and components thereof

A medicinal inhalation device having applied to a surface thereof a composition comprising a multifunctional polyfluoropolyether silane.

A medicinal inhalation device having a non-metal coating coated on at least a portion thereof, and onto which non-metal coating an at least partially fluorinated compound is then covalently bonded.

A medicinal inhalation device having a non-metal coating applied by plasma deposition under ion bombardment conditions.

A pharmaceutical aerosol formulation comprising particles of (a) formoterol or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof and (b) mometasone or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof dispersed in a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane and a mixture thereof, and a bulking agent having a mass median diameter of less than one micron.

Formoterol and mometasone aerosol formulations

Pharmaceutical suspension aerosol formulations containing a therapeutically effective amount of a drug and HFC 134 , HFC 227, or a mixture thereof.

Suspension aerosol formulations

A metered dose aerosol valve that minimizes loss of prime and loss of drug dose by having a one-way valve mechanism positioned toward the end of a transfer passage that allows drug substance to pass from the aerosol container into the metering chamber, but not back.

Metered dose dispensing aerosol valve

A pharmaceutical suspension formulation suitable for aerosol administration having from 0.0025 to 0.1% w/w of micronized Formoterol, or an acid addition salt thereof, from 0.1 to 5.0% w/w ethanol, HFA 134a, HFA 227 or a mixture of HFA 227 and HFA 134a, and optionally a surfactant other than a monoacetylated or diacetylated monoglyceride, the formulation being further characterized in that it exhibits substantially no growth in particle size or change in crystal morphology of the drug over a prolonged period, is substantially and readily redispersible, and upon redispersion does not flocculate so quickly as to prevent reproducible dosing of the drug.

Medicinal aerosol formulations of formoterol

A pharmaceutical aerosol formulation, suitable for administration by oral or nasal inhalation, containing a suspension of particulate budesonide, hydrofluoroalkane propellant and, optionally, additional hydrofluoroalkane propellants, surfactant selected from oleic acid, sorbitan oleates and lecithin, and adjuvant have a Kauri-butanol value of at least 10.

Growing community of inventors

Loughborough, United Kingdom

Philip A Jinks