Biomatrix, Inc.

Union Carbide Corporation

Union Carbide Chemicals and Plastics Company, Inc.

Union Carbide Chemicals & Plastics

John Morris Co., Inc.

Philip A Band

Adolf Leshchiner

Emmett Malone Partain, Iii

Errol D Goddard

Joseph P Pavlichko

Arminda G Barbone

George L Brode

Endre A Balazs

Pak S Leung

Adelya Leshchiner

John Rothman

Nancy E Larsen

Binary polymer mixtures of albumin and glycosaminoglycan and ternary polymer mixtures of polyionic polypeptide and high molecular weight and highly charged polyanions are useful for managing skin including wrinkles or other irregularities. Aqueous compositions of the ternary mixtures have pH dependent phase change properties and provide skin activated films.

Polymer mixtures useful in skin care

Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16.degree. C. at very high pH, e.g., 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.

Hylan preparation and method of recovery thereof from animal tissues

This invention relates to activated protein-containing compositions comprising reducing agents, oxidizing agents and/or anti-oxidants and methods of use. The therapeutic compositions and methods of the present invention are particularly effective in promoting wound healing, and in inhibiting certain skin disorders, including eczema and seborrhea, sclerodema and acne. The therapeutic compositions and methods of the present invention have also shown enhanced effect as veterinary tools in reducing the debilitation associated with certain skin conditions in mammals including eczematoid dermatitis, chronic dermatitis, equine exuberant granuloma ('proud flesh'), decubitis ulcers, and canine cutaneous granulomas ('lick' granuloma).

Compositions and methods for treating skin conditions and promoting

Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.

Processes for managing keratinous material using glycosaminoglycan and

Glycosaminoglycan and cationic polymer combinations

Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0.005-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronic acid molecular chains. Also disclosed is a method of obtaining hylan comprising treating hyaluronic acid in situ in animal tissues containing same with a treatment mixture including a reagent (typically an aldehyde) which is reactive towards hyaluronic acid and the proteins contained in the animal tissue.

Chemically modified hyaluronic acid preparation and method of recovery

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Brooklyn, NY, United States of America

Philip A Band