Carnegie Mellon University

Allegheny-singer Research Institute

Carmell Therapeutics Corporation

University of Pittsburgh

Carnell Therapeutics Corporation

Phil G Campbell

Lee E Weiss

James E Burgess

Jason Smith

O Burak Ozdoganlar

Prashant Nagesh Kumta

Marcel Pierre Bruchez

Geza Erdos

Jonathan W Jarvik

Jeffrey O Hollinger

Charles S Sfeir

Louis D Falo, Jr

Toygun Cetinkaya

Daiwon Chol

Louis Falo

Daiwon Choi

Liliana Camison Bravo

Lucas A Dvoracek

Jesse A Goldstein

David M Sipe

Gregory W Fisher

Alan West

Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.

Biosensor tattoos and uses therefor for biomarker monitoring

A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.

System and method for fabricating cartilage implants

Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.

Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom

A method of making a bioplastic, and a bioplastic produced thereby, by using human plasma in which human plasma is clotted, either dried through its gel phase or dried and powdered, and processed into a bioplastic with the addition of at least one plasticizer followed by forming and heating to form a final bioplastic construct.

Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom

Provided is a method for production of nanocrystalline hydroxyapatite particles, and nanocrystalline hydroxyapatite particles produced according to the method. The nanocrystalline hydroxyapatite particles exhibit substantially superior cell transformation abilities as compared to known and commercially-available calcium phosphate kits. The nanocrystalline hydroxyapatite particles also find use in tissue engineering applications, for example bone and tooth engineering and repair applications.

Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids

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Cranberry Township, PA, United States of America

Phil G Campbell