University of Georgia Research Foundation, Inc.

Phil D Lukert

Branson W Ritchie

Frank D Niagro

Steven E Poet

Denise Pesti

Vaccine compositions which are protective against circovirus infections, including porcine circovirus and psittacine beak and feather disease virus, in animals, comprising a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an animal circovirus polypeptide, wherein the nucleic acid lacks a viral origin of replication are disclosed. Nucleic acid vectors for the transient expression of one or more circovirus polypeptides in a eukaryotic cell comprising a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to the nucleic acids of the invention are described. Methods of preventing a circovirus-associated disease in an animal comprising administering to the animal a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an animal circovirus polypeptide, wherein the nucleic acid lacks a viral origin of replication are also described. Methods of preventing a circovirus-associated disease in an animal comprising administering to the animal an immunogenic amount of one or more animal circovirus polypeptides are also described. Also disclosed are nucleic acid and polypeptide sequences useful in the vaccine compositions and methods of the invention.

Vaccines against circovirus infections

The present invention provides a vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order which comprises an immunogenic amount of a modified live avian polyomavirus in a pharmaceutically acceptable carrier. Methods are also provided for preventing avian polyomavirus infection in a bird, or in several different species of birds, classified as being a member of the Psittaciformes order, comprising administering a vaccine comprising an immunogenic amount of a modified live avian polyomavirus and a pharmaceutically acceptable carrier. A preferred embodiment provides a modified live avian polyomavirus vaccine for prevention of wild-type infection in a Budgerigar, lovebird or Cockatiel.

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Colbert, GA, United States of America

Phil D Lukert