Abbvie Inc.

Phil B Cox

Arthur Gomtsyan

Philip R Kym

Jerome F Daanen

Michael E Kort

Robert G Schmidt

Bruce Clapham

Michael J Dart

Erol K Bayburt

Eric A Voight

Anil Vasudevan

Gregory A Gfesser

Kristine E Frank

Kenton L Longenecker

Michael M Friedman

Noel S Wilson

Eric C Breinlinger

Justin D Dietrich

Augustine Osuma

Huan-Qui Li

Ann Marie Rowley

Stevan Wakefield Djuric

Clara I Villamil

Kevin R Woller

Tammie K Jinkerson

Mark A Matulenko

Ryan G Keddy

Amanda W Dombrowski

The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Tricyclic modulators of TNF signaling

Disclosed herein are modulators of TRPV3 of formula (I) wherein G, X, X, X, X, X, G, Z, R, R, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

TRPV3 modulators

Disclosed herein are modulators of TRPV3 of formula (I) wherein X, X, R, R, R, and n are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Disclosed herein are modulators of TRPV3 of Formula (I) wherein p is 1, 2, 3, or 4, and G, X, X, X, X, X, G, Z, R, R, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Disclosed herein are modulators of TRPV3 of formula (II): wherein G, X, X, X, X, X, G, R, R, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

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Grayslake, IL, United States of America

Phil B Cox