Upm-kymmene Corporation

Petter Somersalo

Marjo Yliperttula

Patrick Laurén

Markus Nuopponen

Kari Luukko

Arto Olavi Urtti

Timo Laaksonen

Arto Merivaara

Tiina Hakkarainen

Heikki Joensuu

Vili-Veli Auvinen

Heli Paukkonen

Outi Monni

Anne Mäkelä

Piia-Riitta Karhemo

Raili Koivuniemi

Yanru Lou

Yan-Ru Lou

Liisa Kanninen

Kirsti Johanna Niklander

Riina Harjumäki

Arto Urtti

Patrick Laurën

Melina Malinen

Johanna Niklander

The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose and freeze-dried cells in an aerogel comprising nanofibrillar cellulose

The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.

Plant-derived nanofibrillar cellulose hydrogel for cell culture and chemical testing

The present invention relates to the use of nanofibrillar cellulose hydrogel in cell culture and medical applications. The invention relates to a composition comprising nanofibrillar cellulose, cross linkable polymer and at least one bioactive agent. The invention also provides methods for producing the composition and uses thereof. The present invention further relates to the use of said composition for manufacturing of a shaped matrix, the method of preparing said matrix, the matrix and the use of said matrix in various applications.

Nanofibrillar cellulose composition

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Helsinki, Finland

Petter Somersalo