Spago Imaging Ab

Spago Nanomedical Ab

Petter Lauritzson

Fredrik Ek

Oskar Axelsson

Rodrigo Petoral, Jr

Jr Petoral Rodrigo M

Rodrigo M Petoral Jr

Disclosed herein are nanostructures comprising a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as &#x2014;RRC(P&#x2550;O(OR)(OR)), wherein Rand Rare independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of Rand Ris a group connected to the polymeric framework with the proviso that when only one of Rand Ris such a connected group, the other of Rand Ris either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, ORand R, wherein Ris a lower alkyl. The polymeric framework may comprise manganese ions. Disclosed are also methods for producing such manganese containing nanostructures, compositions comprising such manganese containing nanostructures and use of such manganese containing nanostructures, i.a. as MRI contrasting agents.

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Hässleholm, Sweden

Petter Lauritzson