Dupont Pharmaceuticals Company

The Dupont Merck Pharmaceutical Company

Petrus Fredericus Stouten

Mimi Lifen Quan

John Matthew Fevig

Robert A Galemmo, Jr

Donald J Pinto

Thomas Peter Maduskuie, Jr

John Wityak

Karen Anita Rossi

James Russell Pruitt

Jung-Hui Sun

Celia Dominguez

Joseph Cacciola

Brian Lloyd Wells

The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH.sub.2 and the other H, and J.sup.1 and J.sup.2 may be O or CH.sub.2, which are useful as inhibitors of factor Xa.

Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and

The present application describes m-amidino phenyl analogs of formula I: ##STR1## wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.

.alpha.-branched anilines, toluenes, and analogs thereof as factor Xa

Isoxazolines, isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds, and methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders. The compounds can be represented by the formula: ##STR1## where X is O, S or NR.sup.15.

Isoxazoline, isothiazoline and pyrazoline factor Xa inhibitors

The present application describes N-(amidinophenyl)cyclourea analogs of formula I: ##STR1## which are useful as inhibitors of factor Xa.

N-(amidinophenyl) cyclourea analogs as factor XA inhibitors

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Wilmington, DE, United States of America

Petrus Fredericus Stouten