Henkel Ag & Company, Kgaa

Basf Se Corporation

Henkel Kommanditgesellschaft Auf Aktien

Petra Siegert

Karl-Heinz Maurer

Timothy O'Connell

Hendrik Hellmuth

Marion Merkel

Susanne Wieland

Ulrich Schwaneberg

Ronny Martinez

Astrid Spitz

Thomas Gerke

Nina Mussmann

Thomas Weber

Bernhard Banowski

Thorsten Bastigkeit

Thomas Eiting

Armin Wadle

Inken Prueser

Cornelius Bessler

Marc-Steffen Schiedel

Konstantin Benda

Stefan Evers

Sven Mueller

Johannes Bongaerts

Brian Laufs

Ayhan Aydemir

Felix Jakob

Dorota Sendor-Müller

Dorota Sendor-Mueller

Sven Müller

Andrea Saettler

Cornelia Kluin

Inken Prüser

Daniele Hoffmann

Timothy O'CONNELL

Cornelius Besseler

Ronny Martinez Moya

Andrea Sättler

The stabilization of a hydrolytic enzyme in a liquid preparation is to be improved through a component that stabilizes the hydrolytic enzyme. This is accomplished by a method for adapting a hydrolytic enzyme to a component that stabilizes the hydrolytic enzyme, comprising the following method steps: a) providing a hydrolytic enzyme (starting enzyme) and a component that stabilizes the hydrolytic enzyme and that comprises a reversible inhibitor of the hydrolytic enzyme; b) changing the amino acid sequence of the hydrolytic enzyme in at least one position, by substitution, deletion or insertion; c) determining the relative activity of the hydrolytic enzyme from step b) and the relative activity of the starting enzyme in a liquid preparation; d) selecting the hydrolytic enzyme that has a reduced relative activity by comparison with the relative activity of the starting enzyme.

Method for adapting a hydrolytic enzyme to a component that stabilizes the hydrolytic enzyme

Proteases encompassing an amino acid sequence that is at least 70% identical to the amino acid sequence indicated in SEQ ID NO. 1 over its entire length, and exhibit the amino acid substitution I21V in the count in accordance with SEQ ID NO. 1, agents that encompass such proteases, display very good cleaning performance on protease-sensitive stains.

Performance-enhanced protease variant

Proteases encompassing an amino acid sequence, which are at least 70% identical to the amino acid sequence specified in SEQ ID NO. 1 over the entire length thereof and which, in the listing according to SEQ ID NO. 1, have the amino acid substitution I21V in combination with at least one further amino acid substitution, the further amino acid substitution being selected from the group consisting of Q12L, M122L, N177V, A222S, V228I and T247N, and agents encompassing such proteases, exhibit very good cleaning performance on egg-containing stains.

Performance-enhanced protease variants

Phosphonate-containing liquid washing or cleaning agent exhibiting advantageous proteolytic activity and improved storage stability comprising a protease having an amino acid sequence which is at least 80% identical to the amino acid sequence stated in SEQ ID NO. 1 and which comprises in position 99 in the numbering according to SEQ ID NO. 1 the amino acid glutamic acid (E) or aspartic acid (D) or the amino acid asparagine (N) or glutamine (Q) or the amino acid alanine (A) or glycine (G) or serine (S).

Storage-stable liquid washing or cleaning agent containing proteases

A hydrolytic enzyme is stabilized in a liquid surfactant preparation using a component that stabilizes the hydrolytic enzyme and encompasses an oligoaminobiphenyl oligocarboxylic acid.

Stabilized liquid tenside preparation comprising enzymes

A hydrolytic enzyme is stabilized in a liquid surfactant preparation using a component that stabilizes the hydrolytic enzyme and includes a phenylalkyldicarboxylic acid.

A hydrolytic enzyme is to be stabilized in a liquid surfactant preparation. This is achieved by using a component that stabilizes the hydrolytic enzyme and encompasses a multiply substituted benzenecarboxylic acid that has a carboxyl group on at least two carbon atoms of the benzene residue.

Stabilized liquid tenside preparation comprising enzymes and benzenecarboxylic acid

A hydrolytic enzyme is to be stabilized in a liquid surfactant preparation. This is achieved by using a component that stabilizes the hydrolytic enzyme and encompasses a phthaloylglutamic acid and/or a phthaloylaspartic acid.

A hydrolytic enzyme is stabilized in a liquid surfactant preparation by using a component that stabilizes the hydrolytic enzyme and includes a monosaccharide glycerate.

Stabilized liquid enzyme-containing surfactant preparation comprising a monosaccharide glycerate

Detergents and cleaning agents containing a protease having an amino acid sequence being at least 97.5% identical to the amino acid sequence given in SEQ ID NO. 3. The detergents and cleaning agents exhibit an excellent cleaning action on protease-sensitive soiling.

[object Object]

A non-therapeutic method for the inhibition of &#x3b2;-glucuronidase. Body odors result from the decomposition of steroid esters by &#x3b2;-glucuronidase. Specific &#x3b2;-glucuronidase-inhibiting compounds are disclosed.

&#x3b2;-glucuronidase inhibitors for use in deodorants and antiperspirants

Growing community of inventors

Haan, Germany

Petra Siegert