Siemens Aktiengesellschaft

Petra Schindler-Bauer

Franz Hofmann

Alexander Frey

Christian Paulus

A method is disclosed for functionalizing biosensors. The biosensors are based on semiconductor chips mounted on a finished processed wafer. They are provided with sensor fields placed thereupon, which are arranged in any array, and, to be precise, for carrying out a functionalization, for example, with organic molecules such as nucleic acids like DNA, RNA and PNA or with their derivatives, proteins, sugar molecules, or antibodies.

Method for functionalizing biosensor chips

Method for detecting macromolecular biopolymers using a unit for immobilizing macromolecular biopolymers, in which the unit is provided with first molecules serving as capture molecules. The method includes the steps of bringing a sample into contact with the unit, it being possible for the sample to contain the macromolecular biopolymers, and the macromolecular biopolymers or the first molecules having a marking which is used to generate a detectable signal, binding macromolecular biopolymers contained in the sample to the capture molecules, thereby forming complexes comprising capture molecules and macromolecular biopolymers, exciting the emission of a signal by means of the marking, detecting the signal emitted by means of the marking, separating the complexes comprising capture molecules and macromolecular biopolymers, thereby altering the intensity of the emitted signal, and detecting the separation of the complexes comprising capture molecules and macromolecular biopolymers by means of the change in the intensity of the signal.

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Vaterstetten, Germany

Petra Schindler-Bauer