Schering Aktiengesellschaft

Petra Rach

Gerald Kirsch

Gunter Neef

Ruth Thieroff-Ekerdt

Katica Schwarz

Matthias Brautigam

Henry Laurent

Dieter Bittler

Andreas Steinmeyer

Michael Topert

Klaus Nickisch

Martin Haberey

Christopher G Earnshaw

R Thieroff-Ekerdt

Andreas Stein-Eyer

Katicia Schwarz

New 24-homo vitamin D derivatives of formula I ##STR1## are described, in which R.sup.1 means a hydrogen atom, a hydroxy, an alkanoyloxy group with 1 to 8 carbon atoms or an aralkanoyloxy group with up to 8 carbon atoms,

24-homo vitamin D derivatives, process for their production and

The invention discloses side-chain homologous vitamin D derivatives of formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, B, and D have the meanings defined in the specification and either (1) A is a direct bond between carbon atoms 20 and 22 and X is an oxy alkylene radical, --(CH.sub.2).sub.n O-- where n is 1 to 3; (2) A is a methylene bridge, --CH.sub.2 --, between carbon atoms 20 and 22 and X is either an alkylene radical, --(CH.sub.2).sub.n -- or an oxy alkylene radical, --(CH.sub.2).sub.n O--, where n is 1 to 3; or (3) if A is a direct bond and B and D together form a second bond, then X(R.sup.5) (R.sup.6) is ##STR2## The compounds possess proliferation-inhibiting and cell-differentiating activity.

Side-chain homologous vitamin D derivatives, process for their

23-oxa-derivatives in the vitamin D series, process for their

New 24-oxa derivatives in the vitamin D series of general formula I are described in which

24-Oxa derivatives in the vitamin D series

Hydroxyalkane carboxylic acid derivatives of general formula I ##STR1## in which n means the numbers 7 to 18,

Hydroxyalkane carboxylic acid derivatives and their production

Androstane derivatives of the general Formula I ##STR1## in which R.sub.1 represents a hydrogen atom or a methyl group,

Androstane derivatives

Dermatics utilizing 17.beta.methyl-18 nor steroids and methods for their

Growing community of inventors

Berlin, Germany

Petra Rach