Bayer Intellectual Property Gmbh

Epicept Corporation

Novosis Ag

Petra Huber

Wilfried Fischer

Michael Dittgen

Thomas Langguth

Stefan Bracht

Dirk Schenk

Clifton Zimmermann

Paul Mason

Katharina Stoeger

Hubert Kaffl

The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly.

Transdermal delivery of hormones with low concentration of penetration enhancers

Transdermal delivery of hormones without the need of penetration enhancers

The present invention refers to a flat self-adhering plaster having a multi-layer construction and reduced cold flow, characterized in that the layer of adhesive possesses a core of adhesive being a flowable adhesive and a ring of adhesive being an adhesive having reduced flowability which surrounds the core.

Patch with reduced cold flow

A non-invasive and non-systemic method for administering a local anesthetic. The method comprises topical application of a local anesthetic in combination with an intradermal-penetration agent selected from the group consisting an aloe composition, a triglyceride, and a mixture thereof.

Intradermal-penetration agents for topical local anesthetic administration

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Munich, Germany

Petra Huber