4sc Ag

Petra Gimmnich

Thomas Beckers

Thomas Maier

Thomas Baer

Matthias Vennemann

Frank Dullweber

Mathias Schmidt

Astrid Zimmermann

Volker Gekeler

Thomas Bär

Klaus Pekari

Beate Schmidt

Steffen Weinbrenner

Hemant Joshi

Alexander Weber

Florian Dehmel

Jürgen Braunger

Uday Joshi

Thomas Stengel

Gudrun Groegor

Kamlesh Padiya

Mahindra Makhija

Dipak Harel

Heike Rothfels

Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors. 

Sulfonylpyrroles

The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases. 

Tetrahydro-fused pyridines as histone deacetylase inhibitors

The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1. 

Thiophene-imidazopyridines

Sulphonylpyrroles

Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective HDAC inhibitors.

Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Tetrahydropyridothiophenes

Compounds of the formula (1) in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity.

Benzothienopyridines for use as inhibitors of Eg5 kinesin

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Constance, Germany

Petra Gimmnich