Amgen Research (munich) Gmbh

Amgen Research Gmbh

Petra Fluhr

Peter Kufer

Tobias Raum

Doris Rau

Evelyne Schaller

Ralf Lutterbüse

Susanne Mangold

Patrick Hoffmann

Roman Kischel

Matthias Klinger

Susanne Hausmann

Carola Steiger

Alexander Murr

Monika Wissinger

Ralf Lutterbuese

Ralf Lutterbuse

The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.

Cross-species-specific PSMAxCD3 bispecific single chain antibody

The present disclosure relates to a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, where the second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7, a pharmaceutical composition comprising the bispecific single chain antibody, and methods for the treatment of an epithelial tumor in a human with the pharmaceutical compositions containing the bispecific single chain antibody. Furthermore, processes for the production of the pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed.

Pharmaceutical compositions with resistance to soluble CEA

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Munich, Germany

Petra Fluhr