Miltenyi Biotec, Gmbh

Leibniz Institute For Natural Product Research And Infection Biology—hans Knoll Institute

Petra Bacher

Alexander Scheffold

Axel Brakhage

Janka Teutschbein

Olaf Kniemeyer

The present invention provides the in-vitro use of at least one in-vivo-target antigen offor selective activation, detection and/or analysis ofspecific CD4T cells in a sample comprising cells, wherein said at least one in-vivo-target antigen reveals an immune reactivity characterized by i) the in vivo existence of antigen-specific T cells comprising more than 60% memory T cells and ii) said antigen-specific T cells further comprise T cells able to produce IFN-gamma upon stimulation at a frequency between 15% and 80% and/or IL17 upon stimulation at a frequency between 5% and 30%. Said at least one in-vivo-target antigen may be selected from the group consisting of antigens Scw4, Pst1, Shm2, GliT and TpiA or fragments thereof. Also provided are a method, a composition, and a kit thereof.

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Berlin, Germany

Petra Bacher