Pliva-lachema A.s.

Petr Sova

Ales Franc

An oral pharmaceutical composition characterized in that it consists of a suspension of a platinum complex of general formula I, wherein A and A' independently of one another are an NHgroup or an amino or diamino group containing 1 to 18 carbon atoms, B and B&#x2032; independently of one another are a halogen atom or a hydroxy group or are an &#x2014;O&#x2014;C(O)&#x2014;R or an &#x2014;O&#x2014;C(O)&#x2014;R&#x2032; group wherein R and R&#x2032; independently of one another are hydrogen atom, an alkyl, alkenyl, aryl, aralkyl, alkylamino or alkoxy group which groups contain 1 to 10 carbon atoms, or functional derivatives of these groups, X and X&#x2032; independently of one another are a halogen atom or a monocarboxylate group containing 1 to 20 carbon atoms, or X and X&#x2032; together form a dicarboxylate group containing 2 to 20 carbon atoms, in at least one pharmaceutically acceptable vegetable, animal, mineral, synthetic or semisynthetic oil and/or in at least one pharmaceutically acceptable vegetable, animal, mineral, synthetic or semisynthetic oily substance, in which suspension the content of the platinum complex of general formula I is 0.5 to 50% by weight based on the total weight of the composition, and which suspension optionally contains at least one pharmaceutically acceptable excipient. 

Pharmaceutical composition for oral administration

An oral pharmaceutical composition for targeted transport of a platinum complex into the colorectal region, includes a mixture of platinum complex of general formula I wherein A each independently is an &#x2014;NHgroup or an amino group containing 1 to 18 carbon atoms, B each independently is a halogen atom, a hydroxy group or a &#x2014;O&#x2014;C(O)&#x2014;R group wherein R each independently is hydrogen atom or an alkyl, alkenyl, aryl, aralkyl, alkylamino or alkoxy group containing 1 to 10 carbon atoms or functional derivatives of these groups, and X each independently is a halogen atom or a monocarboxylate group containing 1 to 20 carbon atoms, or X together form a dicarboxylate group containing 2 to 20 carbon atoms, and at least one excipient selected from the group including a saccharide, oligosaccharide, polysaccharide, modified polysaccharide mucopolysaccharide, protein, oligoprotein, polyprotein, mucoprotein, peptide, oligopeptide and polypeptide, and optionally a lubricant and/or disintegrant, which mixture is optionally compressed into a tablet or contained in a capsule, and this tablet or capsule is optionally coated with a biodegradable layer and/or an outer pH-sensitive colonic layer, and a method of manufacturing and using the composition for treatment of colorectal carcinoma.

Oral pharmaceutical composition for targeted transport of a platinum complex into the colorectal region, method for producing and use as medicament thereof

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Hradec Králové, Czechia

Petr Sova