Magnisense Technology Limited

Uchicago Argonne, LLC

Ceramoptec Industries, Inc.

Other

Petr Ivanovich Nikitin

Petr Nikitin

Petr Mikhailovich Vetoshko

Elena A Rozhkova

Valentine Novosad

Boris Georgievich Gorshkov

Anatolii Beloglazov

Maxim Nikitin

Jean-Marie Billiotte

Stephane Legastelois

A significant enhancement of detection capabilities of the room temperature MPQ is seen using optical lithography-defined, ferromagnetic iron-nickel alloy microdisks. Irreversible transitions between strongly non-collinear (vortex) and a collinear single domain states, driven by an ac magnetic field, translate into a nonlinear magnetic response that enables ultrasensitive detection of material at relatively small magnetic fields.

Ferromagnetic particles as ultra-sensitive non-linear response labels for magnetic particles imaging (MPI) and sensing applications

Method for detecting and quantifying an analyte in a liquid sample, using a test strip and magnetic particles as a detectable label and based on the detection of an amount of magnetic particles which become bound to a reading zone of a test strip as a result of performing the method, said amount being linked through a function to the analyte content of the sample, wherein the magnetic particles exhibit a nonlinear magnetization characteristic, which test strip is made of porous material and is arranged inside a case, cartridge or the like to form an assay device, wherein in its part surrounding the reading zone, the case is made of a material that is permeable to magnetic field, wherein for the reading of the reaction, the assay device is positioned in a measure cell of a magnetic reading device which detects the amount of magnetic particles in the reading zone by submitting it to at least one excitation magnetic field having about 90% of its power within one frequency band or a plurality of frequency bands, and the reading device measures the induced magnetic response field outside said frequency band or said plurality of frequency bands.

Magnetic immunochromatographic test method and device

Disclosed is an apparatus for analysis of a mixture of biological and/or chemical components that exposes a spatially arranged chosen component attached to magnetic particles to a magnetic field and records a magnetic induction signal from which the content of the biological and/or chemical components is determined. The magnetic field is alternating and has a pre-set spectrum at least at two frequencies. The apparatus records the signal at a frequency which is a linear combination of the at least two frequencies while the magnetic particles are exposed to the magnetic field.

Method of analysis of a mixture of biological and/or chemical components with the use magnetic particles and apparatus for its embodiment

Apparatus for detecting biological or chemical components in liquid or gas is based on measuring changes of the sensor layer thickness due to binding reactions. A plate or a gap with two surfaces of a solid optical material is used as the sensor layer. The surfaces are located at a distance of more than 10 &#x3bc;m, which allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of the superluminescent diodes as light sources, because it allows recording within their narrow spectrum a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher sensitivity of the apparatus as compared with apparatus based on thin-film sensor layers.

Method of optical detection of binding of a material component to a sensor substance due to a biological, chemical or physical interaction and apparatus for its embodiment (variants)

Disclosed is a method of analysis of a mixture of biological and/or chemical components that entails spatially arranging a chosen component attached to magnetic particles, exposing the particles to a magnetic field, and recording a magnetic induction signal, from which the content of the analyte in the mixture is judged; this includes grouping the chosen component in a probe volume, making the magnetic field alternating, pre-setting its spectrum, at least, at two frequencies, and recording the signal at a frequency, which is a linear combination of these frequencies, during the exposure of the magnetic particles to the field.

Method for analyzing a mixture of biological and/or chemical components using magnetic particles and device for the implementation of said method

Method for detecting biological or chemical components in liquid or gas is based on measuring changes of the sensor layer thickness due to binding reactions. A plate or a gap with two surfaces of a solid optical material is used as the sensor layer. The surfaces are located at a distance of more than 10 &#x3bc;m, which allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of ultra bright superluminescent diodes as light sources, because it allows recording within their narrow spectrum a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher sensitivity of the method as compared with thin-film methods.

Method for optical detection of an adjoining of a material component to a sensor material with the aid of biological, chemical or physical interaction and device for carrying out said method (variants)

The invention relates to non-contact methods of examining physical and chemical parameters of various media, particularly, gases or liquids. It can be used to determine properties and compositions of media including those containing various chemical or biological components with applications in scientific research, technology and environmental monitoring.

Real time monitoring of medium parameters

The invention relates to non-contact methods of examining parameters of external actions on various media or objects. Such an action could be of various types, e.g., physical (pressure, heating, electric or magnetic field etc.), chemical (action of various chemical substances and associated reactions: binding, replacement, catalysis etc.), biological (action of microorganisms or viruses on a nutrient medium). The invention can be used in scientific research, technology and environmental monitoring.

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Moscow, Russia

Petr Nikitin