Synthon B.v.

Petr Mitas

Lisardo Alvarez Fernandez

Jiri Bartl

Jose Velada Calzada

Luis Nogueiras Nieto

Rohit Kumar

Marta Vivancos Martinez

Libor Vyklicky

Oldrich Smekal

Bohumil Dymacek

Lisardo ÁLvarez FERNÁNDEZ

The present invention relates to a process for preparation of palbociclib, compound of formula (1) or a salt thereof, wherein an intermediate, compound (2), is formed by reacting a compound of formula (3) and a compound of formula (4) in a solvent mixture comprising methanol and butanol: The intermediate (2) can be transformed into palbociclib or a salt thereof.

Process for making palbociclib

The present invention related to a process for preparation of compound of formula (1) or a salt thereof (i.e.) palbociclib: The invention also relates to a solid crystalline form of intermediate of formula (2) used in the process:

The present invention relates to a pharmaceutical composition comprising a physical mixture of sacubitril sodium and valsartan disodium, wherein the X-ray powder diffraction pattern of valsartan disodium comprises characteristic peaks at the following 2 theta (&#xb1;0.2) angles: 4.70&#xb0;, 9.29&#xb0;, 22.34&#xb0;, measured using a Cu K&#x3b1; radiation. The invention further relates to the use of said pharmaceutical composition as medicament in the treatment of heart failure.

Pharmaceutical composition comprising sacubitril and valsartan

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Petr Mitas