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Nikitin, Petr Ivanovich

Petr Ivanovich Nikitin

Jean-Marie Billiotte

Frédéric Basset

Petr Mikhailovich Vetoshko

Boris Georgievich Gorshkov

Andrei V Kabashin

Anatoly A Beloglazov

Stéphane Legastelois

A method for detecting binding of biological and/or chemical components of liquid or gaseous mixtures and solutions, which are of mainly biological origin and/or determine parameters of living activity of biological objects, to substances that bind said components due to a biological, chemical or physical interaction; and analysis of mixtures and solutions to determine presence of biological and/or chemical components. Binding substances are arranged on a surface of or inside a sensor layer, which changes its thickness due to the binding being detected; the layer is affected by light of different wavelengths; a signal due to interference on the sensor layer is registered in the reflected or transmitted light.

Method of optical detection of binding of a material component to a sensor substance due to a biological, chemical or physical interaction and apparatus for its embodiment (variants)

Examinations of biological, biochemical, and chemical characteristics of media, mainly of biologic origin, or media that are in contact with biological objects whose living is influenced by the media characteristics. One excites surface plasmon polaritons on a metal layer covered with a material sensitive to the examined characteristics of a medium, produces an interference with a beam of radiation reflected under these conditions and a reference beam, records parameters of a spatial intensity distribution in the resulting interference pattern, and judges the examined characteristics on the basis of the recorded parameters. The proposed method and apparatus ensure the technical result that consists in upgrading of sensitivity and resolution of measurements, at least, by two orders.

Method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodiment

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Moscow, Russia

Petr Ivanovich Nikitin