Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Ustav Makromolekularni Chemie Av Cr, V.v.i.

Univerzita Palackeho V Olomouci

Masarykova Univerzita

Vysoka Skola Chemicko-technologicka V Praze

Univerzita Karlova V Praze, Prirodovedecka Fakulta

Agra Group, A.s.

Fakultni Nemocnice U Sv. Anny V Brne

Ustav Organicke Chemie a Biochemie Akademie Ved Ceske Republiky, V.v.i.

Ustav Molekularni Genetiky Akademie Ved Ceske Republiky, V.v.i.

Ustav Anorganicke Chemie Akademie Ved Ceske Republiky, V.v.i.

Ustav Anorganicke Chemie Av Cz

Department of Virology, University of Heidelberg

Ustav Organicke Chemie a Biochemie Av Cz

Petr Cigler

Jan Konvalinka

Jan Havlik

Frantisek Sedlak

Pavel Majer

Marian Hajduch

Petr Dzubak

Pavel Krejci

Karel Ulbrich

Pavel Sacha

Jiri Schimer

Jiri Strohalm

Tomas Knedlik

Vaclav Navratil

Vladimir Subr

Vladimír Král

Lukas Balek

Jaromír Plesek

Martin Lepsík

Jana Pokorná

Hans-Georg Kräusslich

Jochen Bodem

Silvie Trantirkova

Lukas Trantirek

Jana Prejdová

Jan Kucka

Martin Hruby

Milan Kozísek

Jan Tykvart

Jiri Brynda

Bohumir Gruner

Pavlina Maloy Rezacova

Pavel Mader

Vaclav Sicha

Mario Bakardjiev

Josef Holub

Bohumír Grüner

Klara Grantz Saskova

Vaclav Vanek

Zuzana Kruzikova

The present invention relates to a process for ion irradiation of a particulate substrate containing the steps of embedding particulate substrate in a solid matrix having 10B atoms, and exposing the matrix obtained in the previous step to a neutron flux to give irradiated particulate substrate. The process is extremely effective and amenable to large scale and is particularly suitable for producing irradiated nanodiamonds and irradiated SiC particles.

Method of production of irradiated particles

Nanodiamonds having a positive &#x3b6;-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive &#x3b6;-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.

Nanodiamonds as artificial proteins for regulation of a cell signalling system

A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.

Macromolecular conjugates for visualization and separation of proteins and cells

Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases. 

Carbonic anhydrase inhibitors and method of their production

The invention relates to a liquid composition containing phosphoric or thiophosphoric triamide derivatives and suitable solvents selected from the group comprising esters of hydroxyacids, heterocyclic alcohols and their derivatives, cyclic carbonic acid esters and dicarboxyacid esters, optionally the composition may also contain glycol ethers and auxiliary substances. The invention further includes the use of this liquid composition as urease inhibitor in urea-containing fertilizers, in fertilizers and wastes of animal origin or in sprays masking animal urine odors.

Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof

The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, &#x2212;1 or &#x2212;2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.

Chemical composition with borane clusters for use as an HIV protease inhibitor

Growing community of inventors

Prague, Czechia

Petr Cigler