Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu

Valeo Systemes Thermiques

Petr Bilek

Jiri Krepelka

Karel Rezabek

Antonin Cerny

Milan Pesak

Bohumil Sevcik

Josef Kral

Josef Picha

Maria Fruhaufova

Antonin Borovicka

Josef Stuchlik

Jana Strakova

Dagmar Picmausova

Petr Zabransky

Radek Hradsky

Jakub Zapotocky

This invention relates to a method for the treatment of endometritis (chronic and/or acute puerperal inflammations) in mammalian females comprising the administration of 1-(8-alpha-ergolinyl)-3,3-diethylurea derivatives of Formula I ##STR1## in which R.sup.1 represents an alkyl group containing 1 to 3 carbon atoms, R.sup.2 represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, and X represents a hydrogen atom or a double bond between the carbon atoms at positions 9 and 10. The compound according to Formula I, or a pharmaceutically acceptable acid addition salt thereof, is the physiologically active component of the therapeutic composition and method. The compound may be combined with a pharmaceutically acceptable diluent, vehicle, excipient, auxiliary, or carrier. The invention is particularly advantageous in veterinary medicine, when applied to the treatment of farm animals, such a cows.

Method for treatment of endometritis in mammalian females

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Prague, Czechia

Petr Bilek