Pharmagra Labs, Inc.

Promerus, Lcc

A.p. Pharma, Inc.

Peter Wyatt Newsome

Albert Roger Frisbee

Sahadeva Reddy Damireddi

Jared K Nelson

Kpakpo Ambroise Akue

Kpakpo Ambrioise Akue

Andrew Bell

Dietrich M Fabricius

Brian F Knapp

Dane Jablonski

Ido Dov Dagan

Michel Pierre Baudet

A Roger Frisbee

Zinovy Itov

April J Morgan

Robert A Noe

The present invention relates to a method of synthesising sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesising a stabilised complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.

Method of synthesising sulforaphane

The present invention relates to a method of synthesising sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesising a stabilised complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent. 

The present invention relates to a method of synthesizing sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesizing a stabilized complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent. 

The present invention relates to methods of isolating and purifying sulforaphane. More specifically, the present invention relates to methods of isolating and purifying sulforaphane from natural sources. The present invention also relates to methods of forming high purity complexes of sulforaphane with cyclodextrin.

Sulforaphane isolation and purification

A method of stabilizing sulforaphane is provided. The method includes contacting sulforaphane, or an analog thereof, and a cyclodextrin to form a complex between the sulforaphane, or analog thereof, and the cyclodextrin.

Stabilized sulforaphane

Embodiments in accordance with the present invention provide for forming essentially pure diastereomers of 5/6-substituted norbornene-type monomers. Further, embodiments in accordance with the present invention encompass polymerizing such diastereomers to form addition or ROMP polymers where a desired exo-/endo-ratio of the diastereomers is provided to the polymerization, such ratio designed to provide a desired ratio of endo-/exo-structured repeating units for a resulting polymer to have desired physical or chemical properties.

Generation of endo- and/or exo-norbornenecarboxaldehyde as an intermediate to functionalized norbornenes

Di(ketene acetals) are prepared by photoisomerizing the corresponding di(vinyl acetals).

Growing community of inventors

Horse Shoe, NC, United States of America

Peter Wyatt Newsome