Medimmune Limited

Spirogen Limited

Peter William Taylor

Philip Wilson Howard

David Edwin Thurston

Stephen John Gregson

Khondaker Mirazur Rahman

Tsveta Stefanova Hadjivassileva

A compound of formula (I) or a salt or solvate thereof, wherein the dotted double bond indicates the presence of a single or double bond between C2 and C3; Ris selected from &#x2014;H, &#x2014;OH, &#x2550;O, &#x2550;CH, &#x2014;CN, &#x2014;R, OR, halo, dihalo, &#x2550;CHR, &#x2550;CHRR', &#x2014;O&#x2014;SO&#x2014;R, COR and COR; Ris selected from H, R, OH, OR, SH, SR, NH, NHR, NRR&#x2032;, nitro, MeSn and halo; where R and R&#x2032; are independently selected from optionally substituted Calkyl, Cheterocyclyl and Caryl groups; Rand Reither together form a double bond, or are selected from H and QRrespectively, where Q is selected from O, S and NH and Ris H or Calkyl or H and SOM, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation; A is selected from (A1), (A2), (A3), (A4) or (A5) where Xand Yare selected from: CH and NH; CH and NMe; N and NMe; CH and S; N and S; N and O; and CH and O, respectively; Xand Yare selected from: CH and NH; CH and NMe; N and NMe; CH and S; N and S; N and O; and CH and O, respectively; Zis selected from O and S; Zis selected from CH and N; F is selected from a single bond and -(E-F)&#x2014;; each E is independently selected from a single bond, and &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;; each Fis independently a Cheteroarylene group; m is 1, 2 or 3; G is selected from hydrogen, Calkyl, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;Calkyl, &#x2014;(CH)&#x2014;Cheterocycloalkyl, and &#x2014;O&#x2014;(CH)&#x2014;Cheterocycloalkyl group; each n is 0-4; provided that A2 is not A2&#x2032;, where Xand Yof A2&#x2032; are selected from: CH and NMe; COH and NMe; CH and S; N and NMe; N and S, respectively; and provided that A3 is not A3&#x2032;, where Xand Yof A3&#x2032; are selected from: CH and NMe; COH and NMe; CH and S; N and NMe; N and S, respectively; B is either a single bond or (B1), where X and Y of B1 are selected from: CH and NMe; COH and NMe; CH and S; N and NMe; N and S, respectively; and Ris Calkyl. 

Pyrrolobenzodiazepines

A compound of formula (I) and salts and solvates thereof, wherein: Ris a nitrogen protecting group and Ris either OH or O&#x2014;R, wherein Ris an oxygen protecting group, or Rand Rtogether form a double bond between N10 and C11; and Rand Rare selected from the same options as Rand Rrespectively. 

Growing community of inventors

London, United Kingdom

Peter William Taylor