Glaxosmithkline Biologicals Sa

Janssen Pharmaceuticals, Inc.

Stichting Katholieke Universiteit / Radboud University Nijmegen Medical Centre

Stitchting Katholieke Universiteit

Peter Wilhelmus Maria Hermans

Michael T Kowarik

Michael L Wetter

Stefan Jochen Kemmler

Manuela Mally

Darren Robert Abbanat

Micha Andres Häuptle

Veronica Gambillara Fonck

Patricia Ibarra Yon

Bert Jacquemyn

Jan Theunis Poolman

Jan Poolman

Oscar Paul Kuipers

Veronica Gambillara

Hester Jeanette Bootsma

Pieter Jan Burghout

Johanna Jacoba Elisabeth Bijlsma

Tomas Gerrit Kloosterman

Michael Thomas Kowarik

Michael Lukas Wetter

Micha Andres Hauptle

Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic(ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates ofpolysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of(EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.

Methods and compositions for immune protection against extra-intestinal pathogenic

The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence ofin vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also antibodies against said protein(s) are included in the invention.

Virulence factors of

The invention relates to the use of a combination of SP1298 and SP2205 proteins or functional fragments thereof or homologous proteins or protein fragments thereof offor preventing or treating ainfection, their use for the preparation of a vaccine for the preventive treatment of ainfection, compositions comprising said proteins ofor functional fragments thereof, vaccines comprising said proteins or functional fragment thereof, and to a method for in vivo immune protection.

[object Object]

Growing community of inventors

Huissen, Netherlands

Peter Wilhelmus Maria Hermans