Roche Molecular Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Peter Wenzig

Thomas Walter

Kurt Weindel

Guenter Ziegler

Jens Christian Bolle

Ursula Giesen

Judith Pinsl-Ober

Erich Kyger

Patrick O'Donnell

Khushbeer Malhotra

Knut Bartl

G&uuml;nter Ziegler

Ralf Schoenbrunner

Jens Bolle

The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent generic binding of nucleic acid molecules to the particles.

Magnetic nanoparticles for nucleic acid purification

Synthesis of magnetic nanoparticles for nucleic acid purification

This invention relates to a method for the isolation of a target nucleic acid using a material with an unmodified silica surface and subsequent amplification of the target nucleic acid in the presence of the material with an unmodified silica surface. The method is preferably carried out as an automated process preferably in a high throughput format. The method is preferably used in diagnostics.

Use of silica material in an amplification reaction

The present invention relates to a method for monitoring a fluid transfer process, including the steps: providing an allowable pressure profile; detecting a pressure occurring in the course of the fluid transfer process; comparing detected pressure with the allowable pressure profile and signaling an error, if the detected pressure is not within the allowable pressure profile. The allowable pressure profile is defined by interpolation points, the interpolation points being based on a probability function representing a family of pressure courses of a plurality of fluid transfer processes. The allowable pressure profile can be divided into at least two distinct process sections, each section corresponding to a distinct process phase of the fluid transfer process. The probability function is calculated from a family of test pressure curves and reflects the statistical behavior of the pipette system. The present invention further relates to a computer readable medium for storing interpolation point information as well as to a kit-of-parts comprising a device implementing the inventive method, together with a computer readable medium for storing interpolation point information.

Method for monitoring a fluid transfer process

The present invention provides a method, an apparatus and a computer program to detect the liquid leakage of a liquid transfer device. In particular, the present invention is directed to a method, an apparatus and a computer program that detects the liquid leakage of a liquid transfer device with electrical means.

Electrical drop surveillance

The combination of two mechanisms of detection in a single device yields a method which allows the simple quantification of analyte determinations. Suitable formats and reagent kits are suggested.

Determination of analytes by means of two markers

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Munich, Germany

Peter Wenzig