Evonik Degussa Gmbh

Symrise Ag

Biosyn Arzneimittel Gmbh

Phytowelt Greentechnologies Gmbh

Biosyn Arzeimittel Gmbh

Wacker Chemie Ag

Jowat Se

Peter Welters

Guido Jach

Thomas Stiefel

Katrin Schullehner

Wolfgang Voelter

Peter Morris

Thomas Haas

Jakob Peter Ley

Harald Haeger

Gerhard Krammer

Andreas Karau

Thorsten Eggert

Ludger A Wessjohann

Lars Mathias Blank

Harald Häger

Andreas Schmid

Volker Sieber

Katrin Grammann

Bruno Buehler

Andrea Weckbecker

Bruno Bühler

Sanae Azdouffal

Bernd Lalla

Frauke Gomoll

Torsten Geißler

Katrin Geißler

Andreas Mueller

Angela Goergen

Andreas MÜLLER

Ingrid Torres Monroy

Carsten Bornhövd

The present invention concerns a method of producing and enantiomerically pure alpha-ionone. Further, the invention concerns a nucleic acid that comprises a sequence that encodes a lycopene-epsilon-cyclase (EC), a lycopene-epsilon-cyclase (EC), plasmids, which encode components of the alpha-ionone biosynthesis and a microorganism that contains heterologous nucleotide sequences which encode the enzymes geranylgeranyl-diphosphate-synthase, isopentenyl-diphosphate-isomerase (IPI), phytoene desaturase-dehydrogenase (crtI), phytoene synthase (crtB), lycopene-epsilon-cyclase (EC) and carotenoid-cleavage-dioxygenase (CCD1). Further, the invention concerns a method of producing highly pure epsilon-carotene.

Method of fermentative alpha-ionone production

The invention relates to providing both fermentative and biotechnological methods for producing 3,4-methylized cinnamic acids, 3,4-methylized cinnamic acid esters, 3,4-dimethoxyphenethylamine, and 4-methylized cinnamic acid amides using a 4'-O-methyltransferase, optionally in combination with further enzymes, wherein the enzymes are selected by means of metabolic engineering and operation have been adapted by targeted optimization, and compositions obtained by means of the method. The invention further relates to vector systems, recombinant microorganisms or fungi, and specific nucleic acid segments and polypeptides.

Method for biotechnological production of methylized cinnamic acids and cinnamic acid esters, methylized phenethylamines and the coupling products thereof, particularly of cinnamic acid amides

The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more &#x3c9;-aminocarboxylic acids, more &#x3c9;-aminocarboxylic acid esters or more lactams derived from &#x3c9;-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of &#x3c9;-aminocarboxylic acids, of &#x3c9;-aminocarboxylic acid esters or of lactams derived from &#x3c9;-aminocarboxylic acids, the &#x3c9;-aminocarboxylic acids, &#x3c9;-aminocarboxylic acid esters or lactams derived from &#x3c9;-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on &#x3c9;-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.

&#x3c9;-Aminocarboxylic acids, &#x3c9;-aminocarboxylic acid esters, or recombinant cells which produce lactams thereof

The present invention relates to processes for the production of mistletoe lectin polypeptides in homologous and heterologous host systems and mistletoe lectin peptides. Further, nucleic acid molecules are provided, which encode these mistletoe lectin polypeptides, and also pharmaceutical compositions comprising mistletoe lectin nucleic acids. The present invention also relates to isolated mistletoe lectin polypeptides and pharmaceutical compositions comprising said polypeptides.

Recombinant mistletoe lectin

The present invention relates to isolated mistletoe lectin polypeptides and the pharmaceutical composition comprising the polypeptides thereof. Also, the present invention relates to processes for the production of mistletoe lectin polypeptides in homologous and heterologous host systems and mistletoe lectin peptides. Further, nucleic acid molecules are provided, which encode these mistletoe lectin polypeptides, and also pharmaceutical compositions comprising mistletoe lectin nucleic acids.

Recombinant mistletoe lectines

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Nettetal, Germany

Peter Welters