Other

Merck Patent Gmbh

Charité – Universitätsmedizin Berlin

Otiscelecator Company

Peter Walden

Michael Wolf

Hans-Dieter Volk

Michael Mann

Markus Weigandt

Hartwig Steckel

Andrea Hanefeld

Stefan Spannhake

Matthias Schroeder

Robert Oesterle

Florian Kern

Gunter Blechschmidt

Michael Bernhard Kocur

Regina Scherliess

Rainer Blasczyk

Percy Knolle

Rodion Demine

Andrea Diedrich

Renato Brito Baleeiro

Alexander Scheffold

The present invention is directed to nanoparticles comprising chitosan and an antigen, whereby the chitosan has a degree of deacetylation of about 90% and a molecular weight from 5 kDa to 80 kDa, to microparticles containing such nanoparticles as well as to a process for preparation of such particles. The particles are usable for vaccination.

Antigen-loaded chitosan nanoparticles for immunotherapy

The invention relates to a method for identifying T-cell stimulating protein fragments using the following steps: a) detecting the amino acid sequence of an antigen; b) subdividing the found amino acid sequence of the antigen into protein fragments; c) synthesizing at least one protein fragment; d) incubating a suspension containing t-cells with the protein fragments; e) identifying an induced T-cell cytokine or activation marker by flow-through cytometry, and; f) assigning the T-cells, with which T-cell cytokines and/or activation markers were identified, to the protein fragments which were incubated with the T-cells. The corresponding protein fragments/peptides are synthetically produced with the assistance of the detected positive sequence, and said corresponding protein fragments/peptides can be utilized to produce a medicament for immunostimulation.

Method for identifying t-cell stimulating protein fragments

The invention relates to a method of peptide sequencing from peptide fragment mass data, wherein a plurality of candidate peptide sequences are determined comprises the steps of: calculating peptide fragment masses, searching a plurality of peak data for masses matching said calculated peptide fragment masses, annotating all permutations of said peak data with amino acid sequences that correspond to the calculated peptide fragment masses, extending said potential sequences to resulting masses with additional matching masses, extending stepwise additions until the resulting masses correspond to parental peptide masses or said parental peptide masses minus the mass of water, and identifying at least one peptide sequence by deleting sequences that can not be extended to endpoints of said parental peptide masses, and deleting identical sequences generated.

Peptide sequencing from peptide fragmentation mass spectra

Method for controlling the drive of a conveyor device ( ), especially in the form of an escalator or moving sidewalk, switchable between load operation and no-load operation, having a drive motor ( ) and a frequency changer ( ) controllable at least with respect to frequency and phase position of its output voltage, in which the drive motor ( ) in load operation is fed with a line voltage with essentially constant line frequency and in no-load operation with the frequency changer output voltage, the phase difference between the phase position of the line voltage and the phase position of the frequency changer output voltage is determined, the phase position of the frequency changer output voltage is corrected according to the determined phase difference and therefore essentially brought into agreement with the phase position of the line voltage and switching is produced as soon as this agreement is reached.

Switch over from the mains supply to a frequency converter by a phase correction process for an escalator drive

Growing community of inventors

Berlin, Germany

Peter Walden