University of California

Tufts College

Peter Tseng

Dino Di Carlo

Ivan Pushkarsky

Fiorenzo G Omenetto

Mark A Brenckle

Bradley Napier

Edward Pao

Amirhossein Hajiaghajani

Logan Garbarini

Coleman Murray

Systems and methods for passive and/or active wireless sensor networks with augmented telemetry using coupled magnetic resonances in accordance with embodiments of the invention are disclosed. In one embodiment, a wireless sensor network is provided, the wireless sensor network comprising a transmitter configured to couple with a reader, a receiver configured to couple with a sensor, wherein the sensor is configured to detect at least one parameter and generate sensor data, wherein the sensor data maps onto the receiver, and wherein the transmitter and the receiver are inductively coupled creating a link between the reader and the sensor.

Augmented telemetry using coupled magnetic resonances

Embodiments herein are directed to a system and a method of selectively manipulating magnetically-barcoded materials from background magnetic materials. Magnetic barcodes include layers of magnetic anisotropy. These are then manipulated by a magnetic system that can drive spatio-temporal magnetic fields that can 'match' a barcode to drive a specific interaction, thereby providing a “lock-key” interaction. This technique is able to selectively manipulate magnetically-barcoded materials, and can have applications across a variety of magnetic systems such as cell separation, drug delivery, valves, and motors.

Electromagnetic systems for the selective manipulation of magnetically-barcoded materials

A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.

Device and method for force phenotyping of cells for high-throughput screening and analysis

This present disclosure provides methods for utilizing such forces in when generating nanofibrillar constructs with engineered morphology from the nano- to macro-scales. Using for example, a biopolymer silk fibroin as a base material, patterns an intermediate hydrogel were generated within a deformable mold. Subsequently, mechanical tension was introduced via either hydrogel contraction or mold deformation, and finally a material is reentrapped in this transformed shape via beta-sheet crystallization and critical point drying. Topdown engineered anchorages, cables, and shapes act in concert to mediate precision changes in nanofiber alignment/orientation and a macroscale form of provided nanofibrillar structure. An ability of this technique to engineer large gradients of nano- and micro-scale order, manipulate mechanical properties (such as plasticity and thermal transport), and the in-situ generation of 2D and 3D, multi-tiered and doped, nanofibrillar constructs was demonstrated.

Biomimetic mechanical tension driven fabrication of nanofibrillar architecture

This disclosure provides a dielectric sensor configured to detect a physiological variable within a subject. The dielectric sensor having at least one split-ring resonator configured to be positioned within an oral cavity of the subject and to be bioresponsive to at least one physiological variable. The split-ring resonator having a first resonator loop, a second resonator loop, and a dielectric interlayer interposed between and contacting the first resonator and the second resonator.

System and method of using a tooth antenna

A system is provided for the quantitative magnetic separation of magnetic objects (e.g., particles or cells). The system uses magnetic ratcheting over arrays of ferromagnetic elements having gradient spacing manifested in various pitch zones that are encountered by the magnetic objects as they traverse the array. The system can be used to separate and concentrate magnetic objects based on iron oxide content. For cells, different phenotypes may be separated based, for example, on surface expression of proteins or molecules that are bound to magnetic particles. The system includes a substrate or chip having the array of ferromagnetic elements with increasing lateral pitch and an externally driven magnet device that generates a cycling magnetic field. Magnetic objects with higher IOC separate and equilibrate along the array at larger pitches. The system can be used for the differential sorting of particles and cells of interest.

Growing community of inventors

Saratoga, CA, United States of America

Peter Tseng