Glycom A/s

Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Other

Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Péter Trinka

Jozsef Reiter

Ferenc Lorant Bartha

Gyula Simig

Tibor Mezei

Gyula Dekany

Gabor Gigler

Markus Hederos

Lars Kröger

Andreas Schroven

Piroska Kovács-Pénzes

Julien Boutet

Ferenc Horváth

Károly Ágoston

István Bajza

Christian Risinger

Lujza E Petocz

Zoltan Budai

Istvan Gyertyan

Istvan Gacsalyi

Markus Jondelius Hederos

Christoph Röhrig

Ioannis Vrasidas

Kálmán Nagy

Ágnes Ágoston

Frigyes Gorgenyi

Kalman Nagy

Pal Fekete

Klara Reiter Nee Esses

Márta Porcs-Makkay

Peter Tompe

Gyula Lukacs

Pal Vago

Gyula Lukács

Sándor Demkó

Zoltán Katona

László Kalmár

Györgyi Vereczkeyné Donáth

Margit Csorgo

Eva Szabo

Janos Brlik

Endre Rivo

Gergely Pipa

József Reiter

László Pongó

Ignacio Figueroa Pérez

Norbert Nemeth

Ilona Sztruhar

Maria Kiraly Nee Ignacz

Peter Slegel

Dezso Danyi

Irme Kovács

Gábor Kádár

Ignacio Figueroa-Pérez

Enikö Molnar

Györgyi Vereczekeyné Donath

Lászlö Pongo

Zsuzsanna Évinger

Enikö Molnár

Gyōrgyi Vereczkeyne Donath

Gyōrgy Clementis

Peter Tömpe

Agnes Halbauer Nee Nagy

Magdolna Kenyeres Nee Feher

Sarolta Benko Nee Markus

Ignacio Figuero-Pérez

Szvetlana Zsarnoczai Nee Kurnyecova

Imre Kovács

Donáth Györgyi Vereczkeyné

The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions. 

Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine

The present invention relates to novel polymorphs of the trisaccharide 2'-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions. 

Polymorphs of 2'-O-fucosyllactose and producing thereof

According to the present invention, 2-chloroethoxy-acetic acid-N,N-dimethylamide of the Formula (I) is prepared by reacting 2-hydroxyethoxy-acetic acid-N,N-dimethylamide of the Formula (II) in a solvent optionally in the presence of a catalyst with thionyl chloride and removing the solvent by distillation. 

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The present invention is related to 1-[(4-chlorophenyl)-phenylmethyl]-4-(2,2,2-trichloroethoxycarbonyl)-piperazine of the Formula (IV) and optically isomers thereof, process for preparation thereof and the use of the compound of the Formula (IV) in the preparation of 1-(4-chlorophenyl)-phenylmethyl-piperazine and optical isomers and salts thereof. 1-(4-chlorophenyl)-phenylmethyl-piperazine and optical isomers thereof are important intermediates in the preparation of non-sedating antihistamine-type active pharmaceutical ingredients. 

Optically active carbamates, process for preparation thereof and use thereof as pharmaceutical intermediates

The invention refers to a novel process for the preparation of {2-[-(&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl groups having 1 to 4 carbon atoms optionally substituted by a phenyl group, alkenyl groups having 2 to 4 carbon atoms or cyclohexyl groups, or the substituents together with the adjacent nitrogen atom of the acetoamido group, form a morpholino group.

Process for the preparation of {2-[4-&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor

This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium. The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds. The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

Process for the preparation of

This invention relates to novel triazolopyrimidine derivatives of formulae (Ia) and (Ib), ##STR1## wherein Q represents hydrogen, a heterocyclic group optionally substituted by a C.sub.1-4 alkyl group and containing one or more oxygen and/or nitrogen atoms or a group of formula

Novel triazolo-pyrimidine derivatives

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Budapest, Hungary

Péter Trinka