Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Peter Tompe

Frigyes Gorgenyi

Daniel Bozsing

Lujza E Petocz

Attila Mandi

Gabor Gigler

Kalman Nagy

Eva J Tajthy Nee Juhasz

Pal Benko

Ivan Beck

Istvan Simonyi

Laszlo Levai

Margit Csorgo

Janos Imre

Eva Furdyga

Erzsebet Kiss Nee Bertok

Gyorgy Mikite

Ilona Dinnyes Nee Nagy

Eva Poczik

Gyorgyi Zalavari Nee Dosa

Gyorgyi Kovanyi Nee Lax

Gyula Simig

Marton Fekete

Istvan Gyertyan

Istvan Gacsalyi

Gabor Blasko

Eniko Szirt Nee Kiszelly

Jozsef Reiter

Pal Fekete

Laszlo Pallos

Edit Berenyi Nee Poldermann

Maria Szecsey Nee Hegedus

Gyorgy Krasznai

Laszlo Varga

Laszlo Rozsa

Agnes Kovacs Nee Palotai

Janos Brlik

Eva Szabo

Erzsebet Barczay

Ilona Sztruhar

Maria Krisztian

Maria Kiraly Nee Ignacz

Sandor Erdos

Peter Slegel

Jozsef Kenderfi

Norbert Nemeth

Eva Hartai Nee Zsorzs

Dezso Danyi

Laszlo Ladanyi

Szvetlana Zsarnoczai Nee Kurnyecova

Sarolta Benko Nee Markus

Magdolna Kenyeres Nee Feher

Agnes Halbauer Nee Nagy

Zoltan Torma

Aranka Hegedus Nee Szima

Gyorgyi Donath Vereczkey

Gabor Nemei

Gyorgyi Lax Kovanyi

The invention relates to a new process for the preparation of amlodipine besylate of the Formula ##STR1## Amlodipine besylate of the Formula I is a valuable known blood pressure decreasing antianginal agent. The advantage of the process of the present invention is that it can be carried out in a simple way with high yields and there is no need to isolate the amlodipine base.

Process for the preparation of a dihydropyridine derivative

This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium. The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds. The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

Process for the preparation of

The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula III

1,4,Dihydro-pyridine intermediates

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.

Process for the preparation of 1,4-dihydro-pyridine derivatives

The present invention relates to a process for the preparation of regulated release solid pharmaceutical compositions comprising 4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyridin e (referred to further on as 'nifedipine') as active ingredient which comprises admixing a solution or solutions of 1 part by weight of nifedipine, 0.1-1.5 parts by weight of one or more hydrophilizing agent(s) and 0.05-1.5 parts by weight of one or more retarding agent(s) formed with one or more identical or different solvent(s) completely or partly and applying the solution(s) thus obtained simultaneously or in succession onto an inert carrier, drying and sieving the product thus obtained and subsequently admixing the same with suitable conventional auxiliary agents and compressing the mixture thus obtained to tablets in a known manner and coating the tablets or filling the mixture into capsules.

Solid pharmaceutical composition and a process for preparing same

The invention relates to new dihydropyrimidothiazine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same and new intermediates useful in the preparation of the said dihydropyrimidothiazine derivatives.

Dihydropyrimidothiazine derivatives

The invention relates to optically active 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxaz ocine of the Formula ##STR1## and pharmaceutically acceptable acid additional salts thereof. The enantiomers are especially active against Parkinsion's disease. The optically active enantiomers are prepared by

Optically active

The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy;

Quinoline derivatives and pharmaceutical compositions

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Budapest, Hungary

Peter Tompe