Bristol-myers Squibb Compnay

Peter T W Cheng

Yan Shi

Sean Chen

Hao Zhang

Shung C Wu

Ying Wang

Denis E Ryono

Joseph Anthony Tino

Wei Meng

Charles Z Ding

Timothy F Herpin

Shiwei Tao

Scott A Bolton

Richard B Sulsky

Pratik Devasthale

Xiang-Yang Ye

Wei Wang

Rebecca A Smirk

Jeffrey A Robl

Jun Li

Ranjan Mukherjee

Sutjano Jusuf

David S Yoon

Lidet A Negash

Zhang Hao

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

Phenyl-(aza)cycloalkyl carboxylic acid GPR120 modulators

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments. 

Cyclobutane containing carboxylic acid GPR120 modulators

Cyclopropanecarboxylic acid GPR120 modulators

The present invention provides compounds of Formula (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments. 

Bicyclo[2.2.2]acid GPR120 modulators

The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments. 

Bicyclo [2.2.1] acid GPR120 modulators

Oxabicyclo [2.2.2] acid GPR120 modulators

Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure is a heteroaryl ring; A method for treating diabetes and related diseases employing the above compounds is also provided.

Substituted pyrazolylamides useful as glucokinase activators

Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure wherein R, R, R, R, R, R, Y and X are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related disease employing the above compounds is also provided. 

Glucokinase activators and methods of using same

Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R, R, R, R, R, R, Rand Rare as defined hereinor a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; Ris alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; Ris alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; Ris as defined herein; Z is O, S, S(O), S(O)2, or NR; X is S, O, N, NR, or CR; Y is NCRor NR; R, R, and Rare as defined herein; Ris aryl, heteroaryl, &#x2014;PO(OR)(OR), &#x2014;PO(OR)Ror &#x2014;P(O)(R)R(wherein Rand Rare as defined herein)/Rand Rare independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided. 

1,3-dihydroxy substituted phenylamide glucokinase activators

Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring;

Substituted pyrazolylamide compounds useful as glucokinase activators

Compounds are provided which have the structure wherein

Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method

Pyrazoloamides are provided which are phosphonate and phosphinate glucokinase activators that are useful in treating diabetes and related diseases and have the structure wherein is a pyrazoyl ring;

Phosphonate and phosphinate pyrazolylamide glucokinase activators

Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein A method for treating diabetes and related diseases employing the above compounds is also provided.

Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R, R, R, R, R, R, Rand Rare as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

Growing community of inventors

Princeton, NJ, United States of America

Peter T W Cheng