Hoffmann-la Roche Inc.

Other

The Penn State Research Foundation

Peter T Lomedico

Ulrich Andreas Gubler

Steven B Mizel

Richard Anthony Chizzonite

Mary-Helen Binger

Werner Altenburger

Stephen J McAndrew

Richard Allen Kramer

The invention relates to the cloning of the human interleukin-1&agr; gene, its engineering into suitable expression vectors, hosts transformed with such expression vectors, and production of biologically active recombinant human interleukin-1&agr;.

Recombinant human recombinant human interleukin-1&agr;

The invention relates to the cloning of the human IL-1 gene, its engineering into suitable expression vectors, transformation of host organisms with such expression vectors and production of biologically active recombinant human IL-1 by culture of such transformed cells. Additionally, the invention relates to the isolation and use of the resulting recombinant human IL-1 polypeptides.

Recombinant human interleukin-1.alpha.

This invention provides DNA sequences coding for Eimeria surface antigens, recombinant vectors containing such DNA sequences, transformed microorganisms containing such vectors, and methods for producing the antigens using the transformed microorganisms. Methods are also provided for protecting poultry against coccidiosis using the Eimeria surface antigens. The surface antigens can be administered for such protection either as purified proteins or in the form of DNA encoding the proteins in a suitable viral vector such as vaccinia virus.

Recombinant coccidiosis vaccines

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Waltham, MA, United States of America

Peter T Lomedico