Duke University

Triad National Security, LLC

Los Alamos National Security, LLC

University of Pennsylvania

Peter T Hraber

Barton F Haynes

Bette T Korber

Hua-Xin Liao

Mattia Bonsignori

Kevin O Saunders

Beatrice H Hahn

George M Shaw

William M Fischer

Feng Gao

Synthetic immunogenic polypeptides based on a curated set of natural alphavirus structural protein sequences are described. The polypeptides were computationally designed to provide optimal coverage of potential immunogenic epitopes of wild-type alphaviruses, including isolates of Venezuelan equine encephalitis virus, Western equine encephalitis virus, Eastern equine encephalitis virus and Chikungunya virus. Sets of immunogenic polypeptides, as well as nucleic acid molecules and vectors encoding the immunogenic polypeptides are also described. The disclosed compositions can be used to elicit an immune response against alphaviruses in a subject.

Alphavirus immunogens and methods of use

In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Compositions comprising HIV envelopes to induce CH235 lineage antibodies

In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections there&#x2014;from, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Compositions and methods for inducing HIV-1 antibodies

In certain aspects the invention provides immunogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.

Compositions comprising CH848 envelopes and uses thereof

In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.

Compositions comprising CH505 envelopes, and trimers

In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Growing community of inventors

Los Alamos, NM, United States of America

Peter T Hraber