Lab-On-A-Bead Ab

Other

Strömberg, Mattias

Nilsson, Mats

Svedlindh, Peter

Göransson, Jenny

Strømme, Maria

Gunnarsson, Klas

Oscarsson, Sven

Nyholm, Leif

Peter Svedlindh

Sven Oscarsson

Kristofer Eriksson

Klas Gunnarsson

Mats Nilsson

Leif Nyholm

Jenny Göransson

Mattias Strömberg

Maria Strçmme

Maria Strømme

A method for the production of particles by reacting functional groups on the surface of non-magnetic porous particles with functional groups on the surface of magnetic particles to form a covalent bond, to obtain particles supplemented with magnetic particles covalently bound to the outer part of said particles. Advantages include an increased binding capacity.

Manufacture of magnetic particles

A novel system for the analysis of molecules and cells, comprising clusters where a non-magnetic particle is supplemented with magnetic particles to form a characteristic pattern, fingerprint or bar code. Methods and devices for formation of such particles are also disclosed.

Diagnostic assay using particles with magnetic properties

There is disclosed a method for partially derivatizing a curved surface of particles in an electrically conducting solvent, said method comprises the steps: a) bringing particles in close contact with at least one surface by using a force, b) inducing a chemical reaction on at least one part of a particle by applying an electrical potential between said at least one surface and the electrically conducting solvent, and c) further reacting said at least one part of a particle where a chemical reaction has been induced in step b) above. There is further disclosed a partially derivatized particle as well as uses of the particle. Advantages include that the method is simple and only requires a potentiostat in addition to standard laboratory equipment, is inexpensive, time-efficient, and inherently parallel.

Partial derivatization of particles

A novel detection or quantifying method for biological entities or molecules such as, but not limited to, DNA, microorganisms and pathogens, proteins and antibodies, that by themselves are target molecules or from which target molecules are extracted, comprises the steps of i) forming target molecule-dependent volume-amplified entities, ii) allowing magnetic nanoparticles to bind to said volume-amplified entities, and iii) measuring changes in dynamic magnetic response of the magnetic nanoparticles caused by the increase in hydrodynamic volume of said magnetic nanoparticles.

Magnetic detection of small entities

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Uppsala, Sweden

Peter Svedlindh