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The Gillette Company

Peter Styczynski

Gurpreet S Ahluwalia

Douglas Shander

Mammalian hair growth is reduced by applying an inhibitor of telomerase to the skin.

Reduction of hair growth

A topical composition useful for reducing in hair growth includes &#x3b1;-difluoromethylornithine and a dermatologically acceptable vehicle comprising at least 4% by weight of a polyoxyethylene ether having the chemical formula R(OCHCH)OH, where R is a saturated or unsaturated alkyl group including from 6 to 22 carbon atoms and b is from 2 to 200.

Hair growth can be reduced using a composition including optically pure L-&agr;-difluoromethylornithine or &agr;-difluoromethylornithine including a preponderance of L-&agr;-difluoromethylornithine.

Mammalian hair growth is reduced by applying to the skin an inhibitor of alkaline phosphatase other than cromoglycate or a salt thereof.

Mammalian hair growth is reduced by applying to the skin a composition that increases cellular ceramide levels.

A method of inhibiting hair growth in a mammal includes applying, to an area of skin from which reduced hair growth is desired, a dermatologically acceptable composition containing a non-steroidal suppressor of angiogenesis.

Inhibition of hair growth

Mammalian hair growth is reduced by applying to the skin an inhibitor of hypusine biosynthetic pathway.

Mammalian hair growth is reduced by applying to the skin an inhibitor of a DNA topoisomerase.

Mammalian hair growth is reduced by applying to the skin an inhibitor of alkaline phosphatase.

Mammalian hair growth is reduced by inhibiting the activity of a matrix metalloproteinase in the skin.

Reduction of hair growth using inhibitors of matrix metalloproteinases

Mammalian hair growth may be modulated by applying to the skin a compound that induces or activates the conjugation of an androgen.

Modulation of hair growth

Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of protein kinase C.

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New Windsor, MD, United States of America

Peter Styczynski