Sandoz Gmbh

Peter Stutz

Paul A Stadler

Anton Stutz

Josef Gottfried Meingassner

Theodor Fehr

Maximilian Grassberger

Helmut Hamberger

Louis A Chedid

Pierre Lefrancier

Georg Bolliger

Hans Fliri

Dieter Scholz

Peter Dukor

Adrian Stephen

Rene Ziegler

The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.

Use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene

New use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.

The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I ##STR1## wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly useful as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises. It is obtained by deprotection of a corresponding compound having one or more hydroxy group(s) in protected form.

Muramyl dipeptide derivatives

Novel N-substituted ergoline- and 9,10-didehydro-8-carboxamide- and -8-aminomethyl-derivatives for the treatment of vascular headaches, especially migraine, and of orthostatic hypotension.

N-substituted ergoline- and

The present invention provides propenylamines useful as anti-mycotic agents.

Propenylamines, processes for their production and pharmaceutical

A 2-methyl-8 (R) or (S) ergot peptide alkaloid in free base form or in pharmaceutically acceptable acid addition salt form is a useful anti-Parkinson agent, prolactin secretion inhibitor, anti-depressant, vigilance-increasing agent, and anti-migraine agent.

Ergot peptide derivatives, their preparation and pharmaceutical

This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,

8.alpha.-Substituted ergoline-I derivatives

The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,

Sulfonamido and sulfamoylamino-ergoline-I derivatives

The invention provides novel penicillins and cephalosporins of formula I, ##STR1## methods for their production and their anti-bacterial use.

Penicillins and their antibacterial use

This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring carbon atom and having 1, 2 or 3 hetero ring atoms, the first hetero atom being nitrogen, oxygen or sulphur, and the second and third hetero atoms, if present, being nitrogen, or 2- or 4-pyridyl monosubstituted by lower alkyl, lower alkoxy or halogen, Useful as anti-Parkinson agents.

6-Methyl-8-thiomethyl-ergolene derivatives

The present invention provides compounds of the formula, ##STR1## wherein R.sub.1 is alkyl (C.sub.1-5),

8-Adamantylaminomethyl ergolene derivatives

Compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms,

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Vienna, Austria

Peter Stutz