Pulmocide Limited

Respivert Limited

Mucovax Inc.

Cmp Therapeutics Limited

Medical Research Council

Plumocide Limited

Peter Strong

Kazuhiro Ito

Stuart Thomas Onions

Peter John Murray

Mihiro Sunose

Thomas Christopher Colley

John King-Underwood

William Garth Rapeport

Garth Rapeport

Catherine Elisabeth Charron

Jonathan Gareth Williams

Simon Fraser Hunt

Vladimir Sherbukhin

Daniel William Brookes

Euan Alexander Fraser Fordyce

Matthew Stephen Coates

David Michel Adrien Taddei

Simon Christopher Hirst

Matthew McConville

Kevin Joly

Ito Kazuhiro

Euan Alexander Fordyce

Lindsey Cass

Howard Clark

Palaniyar Nadesalingam

Kenneth B Reld

Jennifer Claire Thomas

Kenneth Bannerman Reid

Robert Fenton

Matthew Mcconville

Scott Crowe

Keith Ray

Catherine Elizabeth Charron

A combination therapy including one or more compounds of formula (I): wherein R represents hydrogen, halo, cyano, Chaloalkyl, Chaloalkoxy, or SONRR, Rand Rindependently represent hydrogen or halo; Rrepresents hydrogen, halo, cyano, Calkyl, Calkoxy, or Chaloalkoxy; Rrepresents halo, cyano, Calkyl, or Chydroxyalkyl; Rrepresents hydrogen or Calkyl; X represents CH or N; Y represents N or CH which carbon atom may optionally be substituted by R, Ror R; Rand Rindependently represent hydrogen or Calkyl; or a pharmaceutically acceptable salt thereof; and a second or further active ingredient.

Process for preparing a compound useful to treat mycoses

A process for preparing a compound of formula (II): includes reacting a compound of formula (VIII): with a compound of formula (XIV): 

This invention relates to compounds which are used in the preparation of the compound of formula (I).

Compounds which are used in the preparation of the compound of formula (I)

A process for preparing a compound of formula (II):  includes reacting a compound of formula (VIII):  with a compound of formula (XIV): 

This invention relates to compounds which are used in the preparation of the compound of formula (II).

Compounds which are used in the preparation of the compound of formula (II)

A process for preparing a compound of formula (I): includes reacting a compound of formula (II): with a compound of formula (III): 

There are provided 5,6-dihydro-4H-dithieno[3,2-b:2',3&#x2032;-d]azepine derivatives(as defined in the disclosure) which are useful in the treatment of RSV infection and for the prevention of disease associated with RSV infection.

Compounds

The invention relates to aqueous suspension formulations of compounds, as defined in the specification and as represented by the compound of formula (I): and to their use in therapy.

Aqueous suspension formulation comprising 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro-phenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl) or a pharmaceutically acceptable salt thereof

There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (I)). 

5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative

A compound of formula (II): or a compound of formula (IV): or a compound of formula (XX): is useful in the treatment of mycoses.

Compound useful to treat mycoses

A process for preparing a compound of formula (I): or a pharmaceutically acceptable salt thereof includes reacting a compound of formula (6): (wherein R is H) with 2-aminocyclohexanol or a salt thereof.

Process for preparing 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro-phenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-N-((1S,2S)-2-hydroxycyclohexyl) benzamide or a pharmaceutically acceptable salt thereof

There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)). 

There are provided 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives which are useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. 

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London, United Kingdom

Peter Strong