Heinrich Mack Nachf

Pfizer Corporation

Heinrich Mack Nachf. Chem-pharm. Fabrik

Heinrich Mack Nachf. Chem.-pharmazeutische Fabrik

Heinrich Mack Nachf. Chem-parm. Fabrik

Peter Stoss

Matyas Leitold

Peter Merrath

Rodney Yeates

Kurt Rader

Elmar Kaes

A method is described for the production of 6,12-dihydro-6-hydroxy-cannabidiol which is obtained by the reaction of olivetol and cis-p-menth-2-ene-1,8,-diol and the reaction thereof to yield trans-delta-9-tetrahydrocannabinol.

Method for the production of 6,12-dihydro-6-hydroxy-cannabidiol and the

Novel aminopropanol derivatives of 1,4:3,6-dianhydro-hexitol nitrates of the general formula I ##STR1## in which X has the meaning given in the specification, processes for their preparation and their use in preventing and treating angina pectoris, systemic hypertension and pulmonary hypertension in mammals.

Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates,

Oxime ethers of 2,6-dioxabicyclo[3.3.0]octanones of the formula I ##STR1## have pharmacological activity and are especially applicable as drugs for the prophylaxis and therapy of cardiac and circulatory diseases.

Oxime ethers of 2,6-dioxabicyclo(3.3.0)octanones, and compositions and

Isohexide nucleosides of the formula I ##STR1## in which R and B have the meaning given in the description, processes for their preparation and their use as medicaments, in particular as cytostatics, virustatics and immunostimulants.

Isohexide pyrimidines triazines, triazoles and imidazoles useful as

Dianhydrohexites of the formula ##STR1## wherein R.sup.1 is hydrogen or benzyl, R.sub.2 is alkyl or omega-theophyllin-7-yl-alkyl, and R.sup.1 and R.sub.2 together with the nitrogen atom to which they are attached form a bicyclic group and R.sup.3 is hydrogen, acyl, pyridylcarbonyl, nitro or a hydroxylamino group, are formed by an analogous method and used as pharmaceuticals in the treatment of heart and circulatory diseases.

Dianhydrohexite derivatives, and their use as pharmaceuticals

The present invention relates to new acyl derivatives of 1,4:3,6-dianhydrohexitols, processes for their preparation and drugs containing the same. The new compounds have a cardiovascular effect and can be used as antihypertensive agents, as peripheral and central vasodilators and as coronary therapeutic agents.

Dihydropyridine derivatives of 1,4:3,6-dianhydrohexitols

A process for the preparation of isosorbide-2-nitrate of the formula ##STR1## comprising contacting isosorbide with a carboxylic acid anhydride in the presence of a metal salt; esterifying the resultant isosorbide-5-acylate with nitric acid; and converting the resultant isosorbide-5-acylate-2-nitrate to isosorbide-2-nitrate by treatment with an alkyl alcohol in the presence of an alkali metal alcoholate.

Process for the preparation of isosorbide 2-nitrate

This invention relates to a process for the production of isosorbide-5-nitrate comprising

Process for the production of isosorbide-5-nitrate

Vincamine saccharinate, a novel derivative of vincamine, and pharmaceutical compositions containing vincamine saccharinate are disclosed. The solubility of vincamine saccharinate in glycerol-ethanol mixtures and the superior taste characteristics of vincamine saccharinate allow the preparation of preferred pharmaceutical compositions in solution form which are suitable for oral administration, especially in the form of drops.

Growing community of inventors

Illertissen, Germany

Peter Stoss