Egis Gyogyszergyar

Egis Gyogyszergyar Nyilvanosan Muekoedoe

Peter Slegel

Gyula Simig

Gabor Gigler

Jozsef Barkoczy

Frigyes Gorgenyi

Jozsef Reiter

Kalman Nagy

Balazs Volk

Pal Fekete

Ferenc Lorant Bartha

Peter Tompe

Adrienn Keszthelyi

Margit Csorgo

Janos Imre

Gyoergy Ruzsics

Janos Brlik

Eva Szabo

Ilona Sztruhar

Maria Kiraly Nee Ignacz

Gyoergyi Kovanyine Lax

Gyoergy Clementis

Valeria Hoffmanne Fekete

Gyoergy Krasznai

Gyoergy Morovjan

Agnes Halbauer Nee Nagy

Magdolna Kenyeres Nee Feher

Sarolta Benko Nee Markus

Szvetlana Zsarnoczai Nee Kurnyecova

Dezso Danyi

The present invention relates to crystalline Form I rosuvastatin zinc (2:1) salt, method of preparation thereof and use thereof as pharmaceutically active ingredient for the treatment of diseases related to lipid metabolism including hyperlipoproteinemia, hypercholesteremia, dyslipidemia and atherosclerosis.

Crystalline form I rosuvastatin zinc salt

This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium. The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds. The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

Process for the preparation of

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Budapest, Hungary

Peter Slegel