Takeda Pharmaceutical Company Limited

Hexal Ag

Takeda Gmbh

Skufca, Peter

Peter Skufca

Markus Rast

Henning Gieseler

Gerhard Becker

Wolfram Steinhilber

Jürgen Volz

Wolfgang Ise

Rudolf Grimm

Fabian Seibert

Jurgen Volz

The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.

Formulation of an antibody and use thereof

The present invention relates to a method of producing syringes. Said method comprises fixing a needle to a syringe body by use of an adhesive followed by subjecting the syringes thus obtained to heat treatment. The invention further relates to a method of reducing leachables and/or extractables in prefilled syringes, said method comprising heat treating pre-fabricated syringes at a temperature of at least 40&#xb0; C. before filling.

Method for reducing leachables and extractables in syringes

Growing community of inventors

Stockach, Germany

Peter Skufca