Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

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Peter Seress

Vilmos Keri

Janos Erdei

Andrea Csorvasi

Eva Gulyas

Gabor Balogh

Zsolt Tomas Suto

The present invention provides a method of preparing and purifying echinocandin-type compounds, such as pneumocandin Bo, WF 11899A, and echinocandin B. These compounds are fermentation products that are used to prepare semi-synthetic products such as the antifungal products Caspofungin, Mycafungin, and Anidulafungin.

Purification processes for echinocandin-type compounds

An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing asp. strain in a submerged medium at a temperature within about 20-30&#xb0; C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.

pH controlled fermentation process for pseudomonic acid production

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Debrecen, Hungary

Peter Seress