Symphogen A/s

Genentech, Inc.

Alk-abello A/s

Genentench, Inc.

La Jolla Institute for Allergy and Immunogy

La Jolla Institute for Allergy and Immunology

Peter Sejer Andersen

Klaus Koefoed

Magnus Strandh

John A Flygare

Thomas Pillow

Richard L Vandlen

Sanjeev Mariathasan

Leanna Staben

Eric J Brown

John Hiroshi Morisaki

Sophie M Lehar

Wouter Hazenbos

Kim Vilbour Andersen

Torben Peter Frandsen

Mikkel Wandahl Pedersen

Michael Kragh

Johan Lantto

Helle Jane Jacobsen

Thomas Tuxen Poulsen

Martine Darwish

Lars Søgaard Nielsen

Byoung Chul Lee

Alessandro D Sette

John Sidney

Lars Soegaard Nielsen

Søren Kofoed Rasmussen

Gitte Lund

Margit Haahr Hansen

Lone Kjær Rasmussen

Claus Lundegaard

Peter Adler Würtzen

Lars Harder Christensen

Peter Adler Wurtzen

Martin B Oleksiewicz

Soren Kofoed Rasmussen

Lone Kjaer Rasmussen

Lars Sogaard Nielsen

Ida Kjaer

Ida Kjær

Thomas H Pillow

Eric Brown

Byoung-Chul Lee

Soren Rasmussen

Lone Rasmussen

Margit H Hansen

The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.

Anti-wall teichoic antibodies and conjugates

The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one humanized anti-HER2 antibody and at least one humanized anti-HER3 antibody, and use of the antibody compositions for treatment of cancer. The invention also relates to the use of antibodies targeting multiple EGFR-family receptors to treat cancer (e.g., pancreatic cancer) and cancer that has acquired resistance to previous therapies.

Methods for treating cancer by administering humanized pan-HER antibody compositions

The invention relates to combinations of peptides or variants thereof derived from a portion of an amino sequence of a house dust mite allergen, e.g. the allergens Der p 1, Der f 1, Der p 2 and/or Der f 2. Such peptides comprise at least one T cell epitope and a significant high number of patients in a worldwide population will have HLA alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by a dust mite.

Peptide combinations and uses thereof in treating dust mite allergy

Humanized pan-HER antibody compositions

The present invention provides a structural characterization platform that can be used to assess the stability of a polyclonal cell line during production, as well as batch-to-batch consistency of the final polyclonal products. The structural characterization platform is based on genetic analysis as well as protein characterization techniques that alone or in combination provides the necessary information to characterize the polyclonal cell line and final products. The collection of different homologous proteins to be analyzed with the platform techniques is for example a recombinant polyclonal antibody or a mixture of monoclonal antibodies.

Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line

The present invention provides a structural characterization platform that can be used to assess the stability of a polyclonal cell line during production, as well as batch-to-batch consistency of the final polyclonal products. The structural characterization platform is based on genetic analyses as well as protein characterization techniques that alone or in combination provide the necessary information to characterize the polyclonal cell line and final products. The collection of different homologous proteins to be analyzed with the platform techniques if for example a recombinant polyclonal antibody or a mixture of monoclonal antibodies.

Multiplex overlap-extension RT-PCR provides an efficient method of linking two or more nucleotide sequences encoding for domains or subunits of a heteromeric protein, in a single reaction. Especially, the linkage of variable region encoding sequences from e.g. immunoglobulins, T cell receptors or B cell receptors is eased with the method of the present invention. This allows for a more efficient way of generating libraries of variable region encoding sequences. The capability to perform the multiplex overlap-extension RT-PCR using template derived from an isolated single cell enables the generation of cognate pair libraries in a high-throughput format.

Method for linking sequences of interest

Growing community of inventors

Vanløse, Denmark

Peter Sejer Andersen